نتایج جستجو برای: intravenous midazolam

تعداد نتایج: 84129  

Journal: :AANA journal 1999
J Nagelhout F Gerbasi K L Zaglaniczny S Fryzel J Hourrigan J Motz F Wakefield T Wigton J Masserant

Midazolam is a short-acting agent used for preoperative and conscious sedation. Despite a relatively short half-life, midazolam sedation contributes to postoperative sedation, delays in discharge, and increased costs. Administration of flumazenil, a benzodiazepine antagonist, can reverse the centrally mediated effects of midazolam and facilitate patient recovery and discharge, thereby reducing ...

Journal: :Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina 2016
Huseyin Toman Atakan Erkılınc Tuncer Kocak Fusun Guzelmeric Omer Faruk Savluk Mevlut Dogukan Goksel Acar

AIM The administration of trans esophageal echocardiography (TEE) may cause nausea, shortness of breath, agitation, emotional distress and pain in patients due to pharyngo-esophageal intubation, which may be partially relieved by sedoanalgesia. The aim of this study was to compare clinical effects of midazolam, midazolam-alfentanil combination and propofol sedation given for sedation and sedoan...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2010
Sara K Quinney Xin Zhang Aroonrut Lucksiri J Christopher Gorski Lang Li Stephen D Hall

The prediction of clinical drug-drug interactions (DDIs) due to mechanism-based inhibitors of CYP3A is complicated when the inhibitor itself is metabolized by CYP3Aas in the case of clarithromycin. Previous attempts to predict the effects of clarithromycin on CYP3A substrates, e.g., midazolam, failed to account for nonlinear metabolism of clarithromycin. A semiphysiologically based pharmacokine...

2017
Pooja G Pandya T Edward Kim Steven K Howard Erica Stary Jody C Leng Oluwatobi O Hunter Edward R Mariano

BACKGROUND Virtual reality (VR) distraction is a nonpharmacological method to prevent acute pain that has not yet been thoroughly explored for anesthesiology. We present our experience using VR distraction to decrease routine intravenous sedation for patients undergoing preoperative perineural catheter insertion. METHODS This 1-month quality improvement project involved all elective unilatera...

Journal: :International journal of advanced research 2022

Background:Endoscopic retrograde cholangiopancreatography (ERCP), often require sedation during the procedure. The most commonly used drugs for this purpose are midazolam and propofol, which as sedative hypnotic agents with minimal analgesic potential. Aims & objectives:Effects of Sedoanalgesia Midazolam/ ketamine long Dexmedetomidine nfusion Rescue propofol alliquotes regimes on hemodynami...

Journal: :Clinical pharmacology and therapeutics 1995
D R Mould T M DeFeo S Reele G Milla R Limjuco T Crews N Choma I H Patel

The pharmacokinetics and pharmacodynamics of midazolam and diazepam were compared after intravenous infusions of 0.03 and 0.07 mg/kg midazolam and 0.1 and 0.2 mg/kg diazepam on four separate occasions in 12 healthy male subjects in a randomized four-way crossover design. The Digit Symbol Substitution Test (DSST) was used as a measure of drug effect. Subjects performed three practice tests befor...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2010
Beth Miskimins Mills Matthew J Zaya Rodney R Walters Kenneth L Feenstra Julie A White Jason Gagne Charles W Locuson

Recombinant cytochrome P450 (P450) phenotyping, different approaches for estimating fraction metabolized (f(m)), and multiple measures of in vivo inhibitor exposure were tested for their ability to predict drug interaction magnitude in dogs. In previous reports, midazolam-ketoconazole interaction studies in dogs have been attributed to inhibition of CYP3A pathways. However, in vitro phenotyping...

2017
Eytan Shtull-Leber Robert Silbergleit William J Meurer

BACKGROUND Implementation of evidence-based treatment for pre-hospital status epilepticus can improve outcomes. We hypothesized that publication of a pivotal pre-hospital clinical trial (RAMPART), demonstrating superiority of intramuscular midazolam over intravenous lorazepam, altered the national utilization rates of midazolam for pre-hospital benzodiazepine-treated seizures, while upholding i...

2014
Katarzyna Wawrzyniak Krzysztof Kusza Jacek B. Cywinski

OBJECTIVES Premedication with clonidine has been found to reduce the bleeding during endoscopic sinus surgery (ESS), therefore lowering the risk of surgical complications. Premedication is an essential part of pre-surgical care and can potentially affect magnitude of systemic stress response to a surgical procedure. The aim of this study was to compare the efficacy of premedication with clonidi...

Journal: :Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 2006
R Harikumar Mehroof Raj Antony Paul K Harish Sunil K Kumar K Sandesh Syed Asharaf Varghese Thomas

BACKGROUND Music played during endoscopic procedures may alleviate anxiety and improve patient acceptance of the procedure. A prospective randomized, controlled trial was undertaken to determine whether music decreases the requirement for midazolam during colonoscopy and makes the procedure more comfortable and acceptable. METHODS Patients undergoing elective colonoscopy between October 2003 ...

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