The kinetics of binding of glucocorticoids to the soluble, specific binding protein of mouse fibroblasts has been examined. The rate at which both potent and weak glucocorticoids achieve binding equilibrium is very slow. Second order rate constants of association range from 3 times 10-5 M- minus 1 min- minus 1 for cortisol to 6.7 times 10-5 M- minus 1 min- minus 1 for triamcinolone acetonide. S...

Corticosteroids are the most widely used class of drugs in dermatology. In the past, allergic contact dermatitis to topical corticosteriods was rarely reported. In this article, we present a case of delayed type hypersensitivity to triamcinolone acetonide.

PURPOSE To report 2 eyes of a patient which developed vitreomacular traction (VMT) 1 month after intravitreal bevacizumab (IVB) injection. MATERIALS AND METHODS A 45-year-old female with bilateral diffuse diabetic macular edema (DME) received bilateral IVB. RESULTS Her initial visual acuity (VA) was 0.15 and 0.2 in OD and OS, respectively. Central foveal thickness (CFT) was 568 and 662 µm i...

The clinical presentation hypopigmentation is a rare complication after intralesional injection of triamcinolone acetonide. A 32-year-old female, yellow race, visited our dermatology department for a hypopigmented patch in right dorsum of her right thumb. The lesion developed after injection of an intralesional corticosteroid. The patient was diagnosed with hypopigmentation secondary to the tri...

BACKGROUND The purpose of this study was to evaluate the complications of a sub-Tenon injection of triamcinolone acetonide in patients with uveitis. METHODS We retrospectively reviewed the records of uveitis cases treated from 1999 to 2003 in Kaohsiung Chang Gung Memorial Hospital. Thirty patients (45 eyes), who received a sub-Tenon injection of 0.5 ml of a triamcinolone acetonide suspension ...

PURPOSE To evaluate possible toxicity of intravitreal Kenalog (commercial triamcinolone acetonide) to the retina of albino rabbits. METHODS Forty-three albino rabbits were injected intravitreally with 0.1 mL of experimental solution to the right eye and 0.1 mL of saline to the left eye (control). Rabbits in Group A (n=28) were injected with 4 mg/0.1 mL of Kenalog suspension; rabbits in Group ...

PURPOSE To demonstrate the efficacy of local corticosteroid therapy for the treatment of eyelid and orbital xanthogranuloma in adults. METHODS We performed a retrospective chart review of six patients receiving local triamcinolone acetonide (40 mg/mL) injections for the treatment of eyelid and orbital xanthogranuloma at the University of Michigan. All patients underwent diagnostic biopsy prio...

OBJECTIVE To look for alterations of glycemic control as a secondary systemic effect of the retrobulbar injection of triamcinolone acetonide in diabetic and non-diabetic patients. MATERIALS AND METHODS We studied 40 patients (25 men and 15 women, 20 with and 20 without diabetes). The injection site in all patients was the retrobulbar space, with one injection of 1ml triamcinolone acetonide (4...

BACKGROUND Despite the myriad options available, there is no universally accepted treatment for keloids. This study has compared intralesional triamcinolone acetonide, 5-fluorouracil, and their combination in treatment of keloids. METHODS In this randomized parallel group study, 60 patients were enrolled and randomly allocated to three groups. Patients received intralesional injections of tr...