Iodine contamination as defined by the combination of a raised (PBI-T(4)I) difference and low (131)I neck uptake was found in 38 (17.5%) of 217 euthyroid patients. Of these, 17 had PBI levels of greater than 20 mug/dl but in the remainder levels were clinically feasible. In only 21 was there a history of exposure to iodine. Two of 12 hypothyroid patients had PBI levels well within normal limits...

Triiodothyronine (T(3)) and thyroxine (T(4)) were measured by immunoassay in the serum and thyroid hydrolysates of control (group A), mildly iodine-deficient (group B), and severely iodine-deficient rats (group C). These results were correlated with changes in thyroidal weight, (131)I uptake and (127)I content as well as with the distribution of (131)I in Pronase digests of the thyroid. There w...

Histologic variants (tall cell, columnar cell, diffuse sclerosing) of papillary thyroid cancer (PTC) have a worse prognosis, as do more invasive variants of follicular type. Intermediate risk of recurrence includes (1) microscopic invasion of tumor into the perithyroidal soft tissues, (2) cervical lymph node metastases, (3) I-131 uptake outside the thyroid bed, (4) aggressive histology, or (5) ...

Thirty consecutive patients with thyrotoxicosis were followed up at monthly intervals for 6 months after treatment with iodine-131. Serum total T4, serum total T3, and serum TSH response to TRH were measured at each review. Biochemical evidence of hypothyroidism (low T4 raised basal TSH) developed in 18 patients 1-4 months after treatment. In 5 of these patients, symptoms and signs of hypothyro...

Objective: The current work was conducted to study the disease status and treatment results of patients with differentiated thyroid carcinoma referred for surgery and for radioactive iodine therapy. Methods: Retrospective review of 174 patients with differentiated thyroid carcinoma referred for surgery and for radioactive iodine therapy in King abulaziz Hospital and Oncology Center, Jeddah, Sau...