BACKGROUND Hereditary Hyperferritinaemia Cataract Syndrome (HHCS) is a rare autosomal dominant disease characterized by increased serum ferritin levels and early onset of bilateral cataract. The disease is caused by mutations in the Iron-Responsive Element (IRE) located in the 5' untranslated region of L-Ferritin (FTL) mRNA, which post-transcriptionally regulates ferritin expression. METHODS ...

The manufacturing sector works as an engine of growth it creates the conducive path for socio-economic development. In said perspective, numerous studied have empirically proved positive contribution in social – economic However, limited studies could examine factors affecting different industries India. Thus, this study assessed determinants annual turnover firms Indian sector. For aforementio...

Recent months have seen intensified global calls for an intellectual property waiver of COVID-19 related vaccines, treatments and products. Where one side the debate elevates Intellectual Property Rights as on obstacle to affordable expeditious access vaccines treatments, other points existing TRIPS flexibilities such compulsory licensing, necessity future innovation well factors manufacturing ...

The system-on-chip (SoC) design paradigm and deep submicron (DSM) technology bring two main challenges to the ASIC design community. The first one is productivity to use millions of gates within ever shorter time-to-market, which is currently tackled with the design methodology based on Intellectual Property Right (IPR) blocks. The second challenge is coping with rapidly changed technology para...

The mounting loss of the traditional knowledge of indigenous peoples presents environmental as well as ethical issues. Fundamental among these is the sustainability of indigenous societies and their ecosystems. Although the commercial expropriation of traditional knowledge grows, rooted in a global, corporate application of intellectual property rights (IPRs), the survival of indigenous societi...

BACKGROUND Pitching is a common mechanism of injury in baseball, with known risk factors for elbow injuries among adolescent pitchers. HYPOTHESIS Elbow injury rates and mechanisms will differ between high school baseball and softball players. STUDY DESIGN Descriptive epidemiology study. LEVEL OF EVIDENCE Level 3. METHODS Baseball- and softball-related injury data from the 2005-2006 thro...

This paper examines the linkages between the system that society uses to incentivize R&D by private innovators in the area of crop improvement on the one hand and the environment on the other. This examination is an important addition to the technology-assessment exercise conducted in the context of transgenic crops since it focuses on the organization of the R&D process rather than on the outp...

The U.S patent system has been under attack for about a decade. One of the main justifications for changing the patent system has centered on the issue of patent quality. According to patent critics, patents are bad or low quality, justifying major changes to the patent examination and review system. I argue that patent quality is a proxy for attacking patent validity, which has a complex histo...