Deferasirox (Exjade, ICL670) is an orally active iron chelator. Two molecules of deferasirox can form a complex with ferric iron (Fe-[ICL670]2) that can be excreted, reducing body iron overload. The blood binding parameters across species and the interaction with human serum albumin were analyzed for deferasirox and its iron complex. Both molecules were very highly bound to plasma proteins in a...

a novel magnetic mixed hemimicell solid phase extraction (mmhspe) technique for speciation analysis of soluble, ferrous and ferric iron in legumes sample by flame atomic absorption spectrometry analysis (faas) was developed. mmhspe system consisting of alumina-coated magnetite nanoparticles (fe3o4/al2o3nps) modified by sodium dodecylsulfate-1-(2-pyridylazo)-2-naphthol (sds-pan) have been succes...

Previous work from our laboratory demonstrated that pyridoxal isonicotinoyl hydrazone (PIH) has in vitro antioxidant activity against iron plus ascorbate-induced 2-deoxyribose degradation due to its ability to chelate iron; the resulting Fe(III)-PIH(2) complex is supposedly unable to catalyze oxyradical formation. A putative step in the antioxidant action of PIH is the inhibition of Fe(III)-med...

Seedlings of endangered Dade County pine, Pinus elliotii var. densa, must survive long enough to form symbiotic associations with ectomycorrhizal fungi that assist uptake of mineral nutrients. Although plants need nitrogen (N), phosphorus (P), and potassium (K) in relatively large quantities, pine seedlings also may need relatively high amounts of iron (Fe). We hypothesized that iron would limi...

Human ferritins sequester and store iron as a stable FeOOH((s)) mineral core within a protein shell assembled from 24 subunits of two types, H and L. Core mineralization in recombinant H- and L-subunit homopolymer and heteropolymer ferritins and several site-directed H-subunit variants was investigated to determine the iron oxidation/hydrolysis chemistry as a function of iron flux into the prot...

Aqueous contaminant removal in the presence of metallic iron (e.g. in Fe(0)/H(2)O systems) is characterized by the large diversity of removing agents. This paper analyses the synergistic effect of adsorption, co-precipitation and reduction on the process contaminant removal in Fe(0)/H(2)O systems on the basis of simple theoretical calculations. The system evolution is characterized by the perce...

The objective of this study is to evaluate the emulsifier role in the synthesis of Iron Polyaniline nanocomposite by in-situ oxidative polymerization of aniline and reduction of Iron ions into Fe nanoparticles. The polymerization of aniline was carried out in the presence of FeCl as oxidizing agent. During the reaction 3 aniline monomers undergo oxidation and form polyaniline (PANI) whereas the...

The micronutrient iron (Fe) is essential for photosynthesis, respiration, and many other processes, but it is only sparingly soluble in aqueous solution, making adequate acquisition by plants a serious challenge. Fe is a limiting factor for plant growth on approximately 30% of the world's arable lands. Moreover, Fe deficiency in humans is a global health issue, affecting 1.62 billion people, or...

Iron deficiency anemia is the most common type of anemia related to malnutrition world wide. It represents a major problem in developing countries, especially in Egypt. The aim of this study was carried out to elucidate the effect of different types of oral iron therapy (used for the treatment of iron deficiency anemia) on some hormones and minerals in anemic rats. Forty weanling male Sprague-D...

An iron diphosphineborane platform that was previously reported to facilitate a high degree of N2 functionalization is herein shown to effect reductive CO coupling. Disilylation of an iron dicarbonyl precursor furnishes a structurally unprecedented iron dicarbyne complex. Several complexes related to this process are also characterized which allows for a comparative analysis of their respective...