It is established that a high-frequency chromosomal deletion of ca. 100 kb accounts for the loss of properties making up the pigmented phenotype (Pgm+) of wild-type Yersinia pestis. These determinants are known to include virulence by peripheral routes of injection, sensitivity to the bacteriocin pesticin, adsorption of exogenous hemin or Congo red at 26 degrees C, and growth in iron-sequestere...

(1) Brief introduction to iron metabolism and the biochemistry of ferritin. (2) Early studies of circulating ferritin. (3) Methods for measuring serum ferritin concentrations -- immunoradiometric, radioimmuno- and enzyme-linked immuno assays based on liver or spleen ferritin -- an evaluation of these techniques. (4) Serum ferritin concentrations in normal subjects -- definition of normality -- ...

Iron plays a crucial role in biochemistry and is an essential micronutrient for plants and humans alike. Although plentiful in the Earth's crust it is not usually found in a form readily accessible for plants to use. They must therefore sense and interact with their environment, and have evolved two different molecular strategies to take up iron in the root. Once inside, iron is complexed with ...

For the fungus Histoplasma capsulatum, and for other microbial pathogens, iron is an essential nutrient. Iron sequestration in response to infection is a demonstrated host defense mechanism; thus, iron acquisition may be considered an important pathogenic determinant. H. capsulatum is known to secrete Fe(III)-binding hydroxamate siderophores, which is one common microbial process for acquiring ...

To better understand the role of iron in driving marine ecosystems, the Southern Ocean Iron Experiment (SOFeX) fertilized two surface water patches with iron north and south of the Antarctic Polar Front Zone (APFZ). Using 1-D coupled biological–physical simulations, we examine the biogeochemical dynamics that occurred both inside and outside of the fertilized patches during and shortly after th...

While previous studies have identified FeMes2(SciOPP) as the active catalyst species in iron-SciOPP catalyzed Kumada cross-coupling of mesitylmagnesium bromide and primary alkyl halides, the active catalyst species in cross-couplings with phenyl nucleophiles, where low valent iron species might be prevalent due to accessible reductive elimination pathways, remains undefined. In the present stud...

CONRAD, MARCEL E., LEWIS R. WEINTRAUB, DAVID A. SEARS, AND WILLIAM H. CROSBY. Absorption of hemoglobin iron. Am. J. Physiol. 2 I I (5) : I I 23-1 I 30. rg66.-Hemoglobin-iron was absorbed by the guinea pig as an iron-containing porphyrin compound. Absorption of both inorganic and hemoglobin-iron occurred primarily in the duodenum but about onethird of the quantity absorbed from the gut can be ab...

This article reviews investigations on the formation of inhomogeneous ferrous (FeII) and ferric (FeIII) oxides in aqueous solution. These globally abundant materials are important extensive fields research including corrosion steels, mineralogy, environmental remediation, biochemistry. Iron polycations consisting FeII FeIII ions bridged by hydroxyl groups oxyanions. Solution conditions such as ...