Mutations that lead to a loss of the copper-containing plasma enzyme ceruloplasmin disrupt mammalian iron homeostasis. The mechanism by which ceruloplasmin mobilizes iron from cell stores has been controversial. We demonstrate that injection of a soluble copper-containing yeast protein Fet3p can restore iron homeostasis in phlebotomized mice with a deletion of the ceruloplasmin gene. These resu...

Three cases of lead poisoning with a hypochromic anaemia, despite adequate iron stores, are presented and discussed.

Exposure to oxygen-rich environments can lead to oxidative damage, increased body iron stores, and changes in status of some vitamins, including folate. Assessing the type of oxidative damage in these environments and determining its relationships with changes in folate status are important for defining nutrient requirements and designing countermeasures to mitigate these effects. Responses of ...

Increased body iron stores are associated with insulin resistance and type 2 diabetes. In conceptual agreement, increased serum ferritin levels are positively associated with the prevalence of the metabolic syndrome in men and adult preand postmenopausal women (1) and with an increased risk of type 2 diabetes in both men (2) and women (2,3). Given that insulin resistance and an increased risk o...

Introduction: Anemia in pregnancy is a significant public health problem especially in developing countries. Iron deficiency anemia in pregnancy may lead to increased risks of preterm delivery, Low birth weight and still birth. This study was undertaken to detect iron deficiency anemia in pregnant women referring to health care centers of Eslamshahr/Iran. Method: In this study, 266 selected pre...

AIM To evaluate reticulocyte hemoglobin (RET-He) vis-a-vis serum ferritin as a marker of bone marrow iron store in iron deficiency anemia (IDA). MATERIAL AND METHODS A hospital based analytic study was conducted among patients (age group 15-65 years) with newly diagnosed and untreated IDA admitted in medicine ward and not suffering from any inflammatory disorders (excluded by C-reactive prote...

BACKGROUND An international, longitudinal medical follow up examination of male professional road cyclists revealed excessively elevated serum ferritin levels. OBJECTIVE To evaluate the importance of elevated ferritin values among professional cyclists, their relationship with age and nationality, and their evolution over 3 years. METHODS Over 1000 serum ferritin values were collected. Othe...

BACKGROUND Iron is a pro-oxidant cofactor that may be linked to atherosclerosis progression. Reduction of body iron stores secondary to blood donation has been hypothesized to reduce coronary risk, but retrospective studies have yielded inconsistent findings. We sought to assess the effects of blood donation frequency on body iron stores and physiological and biochemical biomarkers of vascular ...

BACKGROUND Increases in stored iron and dietary intake of iron during space flight have raised concern about the risk of excess iron and oxidative damage, particularly in bone. OBJECTIVES The objectives of this study were to perform a comprehensive assessment of iron status in men and women before, during, and after long-duration space flight and to quantify the association of iron status wit...

Physiological control over iron balance is normally exercised through the regulation of iron absorption. Although it is known that the intestinal epithelium can reject unwanted dietary iron or absorb increased amounts when stores are low it is not known how iron crosses the epithelial cell or how this regulation is mediated. The principal factors which affect absorption are those acting in the ...