نتایج جستجو برای: irs2
تعداد نتایج: 621 فیلتر نتایج به سال:
The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis. We have uncovered unexpected roles for the Lin28/let-7 pathway in regulating metabolism. When overexpressed in mice, both Lin28a and LIN28B promote an insulin-sensitized state that resists high-fat-diet induced diabetes. Con...
Purpose: To investigate the genetic polymorphisms that may contribute to the worsening of insulin resistance in type 2 diabetes mellitus (T2DM) with severe or acute hyperglycemia. Methods: This is a prospective cohort study involving 156 T2DM patients with severe or acute hyperglycemia from all medical wards of the National University of Malaysia Medical Centre (UKMMC) that were placed on insul...
Abstract A four-epoch monitoring program spanning ?three months (from 2020 January 8 to April 7) for ammonia, water, and methanol transitions toward the high-mass star-forming region W51 IRS2 was conducted using Shanghai 65 m Tianma Radio Telescope with its K -band (18–26.5 GHz) receiver. In total, 33 ammonia 16 were detected target at least once during this program. Among them, 14 4 show maser...
The European VLBI Network (EVN) has been used to make phase referenced, wide-field (several arcminute) spectral line observations of the 6.7-GHz methanol maser emission towards W51. In the W51main region, the bulk of the methanol is offset from an UCHii region. This probably indicates the methanol emission arises at the interface of the expanding UCHii region and not from an edge-on circumstell...
After our first tentative detection of the molecular oxygen 16O18O isotopomer obtained during the winter ’92/93 (Pagani et al. 1993), we attempted to confirm our results by making a deep search in other sources and in other positions in L134N. We have not been able to confirm the original detection in any other place in L134N but we obtain good upper limits towards NGC 2264(IRS2), TMC2, OMC3 an...
Our analysis of the tumors of 57 women with metastatic breast cancer with next generation sequencing (NGS) demonstrates that each patient's tumor is unique in its molecular fingerprint. We observed 216 somatic aberrations in 70 different genes, including 131 distinct aberrations. The most common gene alterations (in order of decreasing frequency) included: TP53, PIK3CA, CCND1, MYC, HER2 (ERBB2)...
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