نتایج جستجو برای: isatin β thiosemicarbazone
تعداد نتایج: 179088 فیلتر نتایج به سال:
Thiosemicarbazone analogs of papaveraldine and related compounds 1-6 were synthesized and evaluated for cytotoxic and antimalarial activities. The cytotoxic activity was tested against HuCCA-1, HepG2, A549 and MOLT-3 human cancer cell lines. Thiosemicarbazones 1-5 displayed cytotoxicity toward all the tested cell lines, while compounds 2-5 selectively showed potent activity against the MOLT-3 c...
The title compound, C(19)H(18)N(4)O(3) [systematic name: (RS)-1-benzyl-3-hy-droxy-3-(2-imino-3-methyl-5-oxoimidazolidin-4-yl)-2,3-dihydro-1H-indol-2-one], was prepared as a racemate (RR and SS) by the aldol condensation of N-benzyl-isatin with creatinine in the presence of sodium acetate in acetic acid. The r.m.s. deviation of the isatin ring system is 0.033 Å. The benzyl group is disordered ov...
Isatin , w hich is the su b stra te fo r industria l syn thesis o f the m ost p o p u la r fabric dye, the indigo, has been sub ject to elec tro ly tic red u c tio n u n d e r a varie ty of experim en ta l cond itions [1,2]. P o laro graphie b ehav io r o f isatin and a varie ty of isatin derivatives has been described in m any of papers [3 -6 ] , H ow ever, m ost o f those rep o rts w ere d...
Nowadays, cancer is one of the main reasons of death between nations caused by different elements such as presence of mutagenic and cancer causing materials in the environment. Isatin and Carbon nanotubes can be used to deliver their cargoes to cells and organs. The potential use of them to treat several types of cancer, with minimal or no toxic effects to normal cells. In the present study, 1,...
In the present work, some new 5-[2(3)-dialkylamino alkoxy] Indole 2, 3-diones were prepared from 5-hydroxy isatin. A mixture of 5-hydroxy isatin, dialkylamino alkylhalide in alcoholic potassium hydroxide was stirred at room temperature for 6 hours to get the 5-[2(3)dialkylamino alkoxy] Indole 2,3-diones. The structures of the products were characterized by IR, NMR, MASS Spectral studies. All th...
In the title compound, C(16)H(13)ClN(4)OS, the isatin ring system is oriented at dihedral angles of 10.60 (7) and 72.60 (3)° with respect to the thio-semicarbazide and 2-chloro-benzyl groups, respectively. The near planarity of the isatin and thio-semicarbazide groups [r.m.s. deviations of 0.0420 and 0.0163 Å, respectively] is reinforced by intra-molecular N-H⋯O and N-H⋯N hydrogen bonds, which ...
The aim of the present study is to synthesize the oxovanadium complex of the V3+ ion with isatin sciff bases. Spectroscopic methods have been used to confirm these models of complexation and to understand the structures of the species formed in methanolic solution. We also have isolated a complex of Vanadium (III) with isatin schiff bases in the solid phase.
Phthiobuzone is a bis(thiosemicarbazone) derivative with a single chiral center which has been used as a racemate in the clinical treatment of herpes and trachoma diseases. In this study, its two enantiomers were prepared from chiral amino acids and their absolute configurations were investigated by electronic circular dichroism (ECD) combined with modern quantum-chemical calculations using tim...
We describe the synthesis and characterization of cobalt(II) and nickel(II) coordination compounds of 4[N-(furan-2'-aldimine)amino]antipyrine thiosemicarbazone (FFAAPTS) and 4[N-(4'-nitrobenzalidene) amino]antipyrine thiosemicarbazone (4'-NO(2)BAAPTS). All the isolated compounds have the general composition MX(2)(L)(H(2)O) (M = Co(2+) or Ni(2+); X = Cl, Br, NO(3), NCS or CH(3)COO; L = FFAAPTS o...
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