Many bioinformatics algorithms can be understood as binary classifiers. They are usually trained by maximizing the area under the receiver operating characteristic ( ) curve. On the other hand, choosing the best threshold for ROC practical use is a complex task, due to uncertain and context-dependent skews in the abundance of positives in nature and in the yields/costs for correct/incorrect cla...

We present a new method for solving total variation (TV) minimization problems in image restoration. The main idea is to remove some of the singularity caused by the non-diierentiability of the quantity jruj in the deenition of the TV-norm before we apply a linearization technique such as Newton's method. This is accomplished by introducing an additional variable for the ux quantity appearing i...

Study #1: We specifically examined resistance artery function from the mesentery, because vasosonstriction of this vascular bed is important for orthostatic tolerance, and because others have reported that there is reduced ability to constrict this vascular bed after hindlimb suspension (McDonald et al., J. Appl. Physiol. 72: 2210-2218, 1992; Overton & Tipton, J. Appl. Physiol. 68: 355-362, 199...

The main theme of this paper is to develop a novel eigenvalue optimization framework for learning a Mahalanobis metric. Within this context, we introduce a novel metric learning approach called DML-eig which is shown to be equivalent to a well-known eigenvalue optimization problem called minimizing the maximal eigenvalue of a symmetric matrix (Overton, 1988; Lewis and Overton, 1996). Moreover, ...

This note points out an error in the local quadratic convergence proof of the predictorcorrector interior-point algorithm for solving the semidefinite linear complementarity problem based on the Alizadeh–Haeberly–Overton search direction presented in [M. Kojima, M. Shida, and S. Shindoh, SIAM J. Optim., 9 (1999), pp. 444–465]. Their algorithm is slightly modified and the local quadratic converg...

This paper proposes a globally convergent predictor-corrector infeasible-interiorpoint algorithm for the monotone semide nite linear complementarity problem using the AlizadehHaeberly-Overton search direction, and shows its quadratic local convergence under the strict complementarity condition.

The IP Lookup Process is a key bottleneck in routing due to the increase in routing table size, increasing traıc and migration to IPv6 addresses. The IP address lookup involves computation of the Longest Prefix Matching (LPM), which existing solutions such as BSD Radix Tries, scale poorly when traıc in the router increases or when employed for IPv6 address lookups. In this paper, we describe a ...

The IP Lookup Process is a key bottleneck in routing due to the increase in routing table size, increasing traıc and migration to IPv6 addresses. The IP address lookup involves computation of the Longest Prefix Matching (LPM), which existing solutions such as BSD Radix Tries, scale poorly when traıc in the router increases or when employed for IPv6 address lookups. In this paper, we describe a ...

• Introduction: Microbial Flow Cytometry: Technology and Applications. Martin G. Wilkinson • Chapter 1: Microbial Cytometry: What It Was, Is, and May Be. Howard M. Shapiro • Chapter 2: Non-Destructive OnChip Imaging Cytometry Assay for Constructive On-Chip Cellomics Studies. Kenji Yasuda • Chapter 3: Application of Flow Cytometry to Environmental Biotechnology. Mónica Herrero and Mario Díaz • C...

Using the demand side approach we construct a new set of estimates of per capita agricultural output and per capita GDP for England over the period 1250-1850. Our estimates of per capita GDP suggest that the pattern of long run growth of the English economy can be interpreted with a periodization in three historical stages. The first stage, covering the period 1250-1580, is a Malthusian phase w...