Non-invasive forearm ischemia-reperfusion injury and low flow induced vascular dysfunction models provide methods to evaluate vascular function. The role of oestrogen, an endogenous anti-oxidant on recovery from ischemia-reperfusion injury has not been evaluated nor has the impact of prolonged low flow on vascular function been established. Eight healthy women (33±10 yr) attended the lab during...

To explore the protective effect of bilobalide on pheochromocytoma cell injury induced by oxygen-glucose deprivation/reperfusion in vitro. simulate ischemia-reperfusion condition, was The cells were divided into control, and deprivation/ reperfusion+bilobalide groups. viability, proliferative capacity, malondialdehyde level, superoxide dismutase apoptosis, Wnt1 protein level nuclear beta-cateni...

Acute myocardial infarction (AMI) is the leading cause of death, morbidity, and health costs worldwide. In AMI, a sudden blockage blood flow causes ischemia cell death. Reperfusion after has paradoxical effects may exacerbate injury, process known as ischemic reperfusion injury. this work we evaluated lipidome isolated rat hearts, maintained in controlled perfusion (CT), undergoing global (ISC)...

3 Introduction 3 Pathophysiological features of reperfusion injury 4 Metabolic changes in myocardial ischemia-reperfusion 7 Oxidative stress in myocardial ischemia-reperfusion 9 Types of antioxidants 11 Role of antioxidants in myocardial ischemia-reperfusion injury 12 Hypothesis 15 Hypothesis 1: Xanthine oxidase inhibitor can protect against myocardial ischemia-reperfusion injury. 15 Hypothesis...

Okaya, Tomohisa, and Alex B. Lentsch. Peroxisome proliferatoractivated receptorregulates postischemic liver injury. Am J Physiol Gastrointest Liver Physiol 286: G606–G612, 2004. First published November 13, 2003; 10.1152/ajpgi.00191.2003.—Peroxisome proliferator-activated receptor(PPAR ) is a transcription factor that in some in vitro systems has been linked with downregulation of proinflammato...

Reactive oxygen species are a major cause of damage occurring in ischemic tissue after reperfusion. During reperfusion transitional metals such as iron are required for reactive oxygen species to mediate their major toxic effects. Xanthine oxidase is an important source of reactive oxygen species during ischemia-reperfusion injury, but not in all organs or species. Because cytochrome P-450 enzy...

Significance: Intraoperative parameters of renal cortical microperfusion (RCM) have been associated with postoperative ischemia/reperfusion injury. Laser speckle contrast imaging (LSCI) could provide valuable information in this regard the advantage over current standard care being a non-contact and full-field technique. Aim: Our study aims to validate use LSCI for visualization RCM on ex vivo ...

AIM To investigate the hypothesis that treatment with dimethyl fumarate (DMF) may ameliorate liver ischemia/reperfusion injury (I/RI). METHODS Rats were divided into 3 groups: sham, control (CTL), and DMF. DMF (25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransfe...

OBJECTIVES The clinical significance of ischemia/reperfusion of the lower extremities demands further investigation to enable the development of more effective therapeutic alternatives. This study investigated the changes in the vascular reactivity of the rabbit femoral artery and nitric oxide metabolites under partial ischemia/ reperfusion conditions following cilostazol administration. METH...

ABSTRACT Purpose To evaluate the preventive cardioprotective effects of resveratrol and grape products, such as juice red wine, in animal model cardiac ischemia reperfusion. Methods Male Wistar rats orally pretreated for 21-days with products were anesthetized placed on mechanical ventilation to surgically induce reperfusion by obstruction (ischemia) followed liberation (reperfusion) blood circ...