نتایج جستجو برای: ischemic white matter

تعداد نتایج: 450059  

2011
Fernando Correa Maxime Gauberti Jérôme Parcq Richard Macrez Yannick Hommet Pauline Obiang Miriam Hernangómez Axel Montagne Géraldine Liot Carmen Guaza Eric Maubert Carine Ali Denis Vivien Fabian Docagne

Tissue plasminogen activator (tPA) is the only available treatment for acute stroke. In addition to its vascular fibrinolytic action, tPA exerts various effects within the brain, ranging from synaptic plasticity to control of cell fate. To date, the influence of tPA in the ischemic brain has only been investigated on neuronal, microglial, and endothelial fate. We addressed the mechanism of acti...

Journal: :Cerebrovascular diseases 2015
Doriana Landi Paola Maggio Domenico Lupoi Paola Palazzo Claudia Altamura Emma Falato Riccardo Altavilla Stefano Vollaro Angela Daniela Coniglio Francesco Tibuzzi Francesco Passarelli Mauro Silvestrini Patrizio Pasqualetti Fabrizio Vernieri

BACKGROUND Over time, exposure to cerebrovascular risk factors and carotid artery disease may cause multiple asymptomatic brain cortical and subcortical microinfarcts, which are commonly found at brain autopsy. So far, lack of convenient neuroimaging tools limited the investigation of grey matter ischemic damage in vivo. We applied the Double Inversion Recovery (DIR) sequence to explore the imp...

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