Replacement in Patients With Isolated Aortic Regurgitation To the Editor: We read with great interest a paper by Chaliki and associates in the November 19, 2002, issue of Circulation.1 In their study, patients with markedly impaired left ventricular (LV) function were compared with those with moderately impaired or normal LV function. Operative mortality was higher among the markedly impaired L...

OBJECTIVES The purpose of this study was to describe the phenotypic characteristics of an inherited myxomatous valvular dystrophy mapped to Xq28. BACKGROUND Myxomatous valve dystrophies are a frequent cause of valvular diseases, the most common being idiopathic mitral valve prolapse. They form a group of heterogeneous diseases difficult to subclassify. The first mapping of the gene for a myxo...

Between June 1969 and August I970, 8o patients, aged 22 to 63 years, had lone aortic valve replacement with frame-mounted autologous fascia lata. The operative mortality was 3.8 per cent. Seventy-seven survivors have been followed for 3 to 4 years and 50 have had postoperative investigation. There have been 8 subsequent deaths, 3 from infective endocarditis, 4 from aortic regurgitation, and one...

Objective: The most appropriate management of aortic stenosis (AS) in children remains controversial. The purpose of this study was to determine the outcome following open valvotomy for AS in children. Methods: Ninety-seven consecutive, unselected, children (mean age 3.2 ^ 3.6 years, 1 day±15 years) underwent an open valvotomy for critical …n ˆ 36† or severe …n ˆ 61† AS between 1979 and 2000 in...

ALTHOUGH many techniques1-12 have been proposed or utilized for the semiquantitative or quantitative assessment of aortic regurgitation, the most direct approach involves measurement of the regurgitant flow by the recording of indicator concentrations from the left ventricle following injection into the aortic root. This method is theoretically valid13 and had been applied to aortic regurgitati...

Despite the frequency of aortic valve (AV) surgery, techniques for AV repair have been adopted more slowly by surgeons when compared to repair techniques for the mitral valve. Undoubtedly the fact that the majority of AV operations are performed to relieve stenosis explains higher rates of AV replacement and reduced opportunities for repair experience. However there is growing recognition that ...

Methods We retrospectively identified 97 consecutive patients with surgically corrected TOF and 26 controls without TOF or aortic or cardiac abnormalities who underwent cardiac MR evaluation. The ascending aortic diameter was measured at four levels and diameter ratios were calculated for morphologic characterization. Aortic pulse wave velocity (PWV) and aortic regurgitation were calculated fro...

Between June 1969 and August I970, 8o patients, aged 22 to 63 years, had lone aortic valve replacement with frame-mounted autologous fascia lata. The operative mortality was 3.8 per cent. Seventy-seven survivors have been followed for 3 to 4 years and 50 have had postoperative investigation. There have been 8 subsequent deaths, 3 from infective endocarditis, 4 from aortic regurgitation, and one...

Objective: To evaluate immediate and midterm results after balloon valvoplasty in a paediatric population with congenital aortic stenosis, giving special consideration to aortic regurgitation. Design: Retrospective study. Setting: Two tertiary referral centres for paediatric cardiology. Patients: 70 consecutive patients, with an age range of 0–16.4 years. Group A infants , 3 months old (n = 21)...

The association of sinuses of Valsalva dilatation and aortic regurgitation with hypertension is disputed, and few data are available in population-based samples. We explored the relations of sinuses of Valsalva dilatation and aortic regurgitation to hypertension and additional clinical and echocardiographic data in 2096 hypertensive and 361 normotensive participants in the Hypertension Genetic ...