Insulin-like growth factor I (IGF-I or somatomedin C) is a serum polypeptide with three intramolecular disulfide bonds. In the course of synthesis by the recombinant DNA method, three disulfide bond isomers, all of which have Cys18-Cys61 with three combinations of two disulfide bonds formed by Cys6, Cys47, Cys48 and Cys52, were identified. Natural type, isomer II, was proved to have a Cys6-Cys4...

Photoresponsive systems for site-selective RNA scission have been prepared by combining Lu(III) ions with acridine/azobenzene dual-modified DNA. The modified DNA forms a heteroduplex with substrate RNA, and the target phosphodiester linkages in front of the acridine residue is selectively activated so that Lu(III) ion rapidly cleaves the linkage. Azobenzene residue introduced adjacent to the ac...

It has been previously reported that the main diene-conjugated fatty acid in human plasma is a non-oxygen containing linoleic acid isomer (PL-9, ll-LA’). It has also been proposed that this isomer can be used as a specific marker of free radical-mediated lipid peroxidation in humans. Here we report that the in vitro induction of lipid peroxidation in human and rat blood with either W irradiatio...

The recently reported heteroleptic cyclometallated iridium(III) complex [Ir(2-phenylpyridine)(2)(2-carboxy-4-dimethylaminopyridine)] N984 and its isomer N984b have been studied more in detail. While photo- and electrochemical properties are very similar, DFT/TDDFT calculations show that the two isomers have different HOMO orbital characteristics. As a consequence, solution processed OLEDs made ...

What Might Be the Positive Spin-Offs Associated With Modafinil or Armodafinil Use in This Patient? Racemic modafinil and its R-isomer armodafinil are approved treatments for the excessive daytime drowsiness associated with narcolepsy, shift work, and obstructive sleep apnea1; therefore, either of these drugs could benefit Mr P. In schizophrenia, modafinil and armodafinil have been prescribed, s...

Three different magnetic samples with particle sizes ranging from 10 to 30 nm were prepared by wet chemical methods. The powders were heated at 100, 150, 200, and 250 °C during 30 min under air. Ferrous and total iron contents were determined immediately after the synthesis and after the thermal treatments. All samples were characterized by X-ray diffraction, transmission and integral low-energ...

The lifetimes of the first excited 2^{+} and 4^{+} states in ^{72}Ni were measured at the National Superconducting Cyclotron Laboratory with the recoil-distance Doppler-shift method, a model-independent probe to obtain the reduced transition probability. Excited states in ^{72}Ni were populated by the one-proton knockout reaction of an intermediate energy ^{73}Cu beam. γ-ray-recoil coincidences...

Geometrical isomers of /.3-diazadiphosphetidines show large differences in their 31P chemical shifts. Trifluoroethoxylation of rä-(PhNPC l) 2 gives only the 'low-field' isomer initially, for which the crystal structure is determined. The compound crystallises in the triclinic space group P 1 with a = 9 .624(4 ).6 = 10 .107(4),c = 11.140(7) Ä ;a = 105.65(4),ß = 110.59(4),y = 93 .82(3)°;and Z = 2...

A systematic process is introduced to compare (13)C NMR spectra of two (or more) candidate samples of known structure to a natural product sample of unknown structure. The process is designed for the case where the spectra involved can reasonably be expected to be very similar, perhaps even identical. It is first validated by using published (13)C NMR data sets for the natural product 4,6,8,10,...

Neutron-rich nuclei in the lead region, beyond N = 126, have been studied at the FRS-RISING setup at GSI, exploiting the fragmentation of a primary uranium beam. Two isomeric states have been identified in 210Hg: the 8 isomer expected from the seniority scheme in the νg9/2 shell and a second one at low spin and low excitation energy. The decay strength of the 8 isomer confirms the need of effec...