The clinical course and outcome of 55 fetuses with complete atrioventricular (AV) block detected prenatally were studied to identify factors that affect the natural history of this lesion. In 29 fetuses (53%) complete AV block was associated with complex structural heart defects, usually left atrial isomerism (n = 17) or discordant AV connection (n = 7). The other 26 fetuses had normal cardiac ...

A previously uncharacterized form of stereochemistry, constellational isomerism, is described. The isomerism arises from different arrangements of small-molecule guests in the space of a self-assembled, cylindrical host. The cylindrical host detains three molecules each of CHCl(3), 1,2-dichloroethane, or isopropyl chloride. The exchange of guests in and out of the host is slow on the NMR time s...

New concepts to design innovating and top-performing redox-active organic molecules based electrodes should push forward and promote an eco-friendly alternative to classical Li-ion batteries. In this promising research area, density functional theory calculations lend support to experiments through the prediction of redox voltage and give promise to rationalize the trends, thus providing a gene...

Leftward fluid flow in the mouse node is generated by cilia and is critical for initiating asymmetry of the left-right axis. Coiled-coil domain containing-40 (Ccdc40) plays an evolutionarily conserved role in the assembly of motile cilia and establishment of the left-right axis. Approximately one-third of Ccdc40lnks mutant embryos display situs defects and here we investigate the underlying mec...

This paper has focused on the optimization of topology control for heterogeneous energy-saving sensor networks. In the heterogeneous sensor networks, there is initial heterogeneous energy in each sensor node which produces isomerism such as heterogeneous link in the process of wireless communication. Compared with the traditional energy conservation optimum algorithm which doesn’t take fully co...

Twelve patients aged between 2 weeks and 22 months (median 6 weeks) with atrioventricular septal defects were examined with a 1.5 T, whole body, magnetic resonance imaging system. Ten patients had a common atrioventricular orifice (complete defect) while two patients had separate right and left valve orifices (partial defect). Associated cardiac malformations included the tetralogy of Fallot in...

NO-donating aspirin (NO-ASA) is a potentially important chemopreventive agent against cancer. Since positional isomerism affects strongly its potency in inhibiting colon cancer cell growth, we studied the metabolic transformations of its ortho-, meta-, and para-isomers in rat liver and colon cytosolic, microsomal, and mitochondrial fractions as well as in intact HT-29 human colon cancer cells. ...

Visceral heterotaxy syndrome causes abnormal arrangement of thoracoabdominal organs and severe complex cardiac anomalies by abnormal laterality. The purpose of the present study is to analyze the incidence and pattern of heterotaxy syndrome in etretinate and all-tran retinoic acid treated pregnant DDY mice. Pregnant DDY mice were intragastrically given a single dose of 15 mg/kg of etretinate at...

Potentiodynamic investigations on a platinum electrode show that oxidation of phenol, monochlorophenols, dichlorophenols, 2,3,6-, 2,4,5-, 2,4,6-trichlorophenols, and pentachlorophenol in 1 M NaOH solution, containing 1 mM of phenols, proceeds in the potential region of Pt oxide formation. The oxidation rate of phenols decreases with the increase in the number of chlorine atoms in the benzene ri...

B y now you should be familiar with position isomers wherein compounds of the same molecular formula differ because substituents, chain branches, and so on, are not at the same positions in the molecules. 1-Chloropropane and 2-chloropropane are straightforward examples of position isomers. A much more subtle form of isomerism is present when two dijfjrerent compounds have the same molecular for...