The contribution of transient outward current (Ito) to changes in ventricular action potential (AP) repolarization induced by acidosis is unresolved, as is the indirect effect of these changes on calcium handling. To address this issue we measured intracellular pH (pHi), Ito, L-type calcium current (ICa,L), and calcium transients (CaTs) in rabbit ventricular myocytes. Intracellular acidosis [pH...

We recently characterized an autocrine renin angiotensin system (RAS) in canine heart. Activation of Angiotensin II Type 1 Receptors (AT1Rs) induced electrical remodeling, including inhibition of the transient outward potassium current Ito, prolongation of the action potential (AP), increased calcium entry and increased contractility. Electrical properties of the mouse heart are very different ...

Transparent conducting electrodes with the combination of high optical transmission and good electrical conductivity are essential and desirable in solar energy harvesting and electric lighting devices including organic solar cells and light-emitting diodes (LEDs) as well as in their inorganic counterparts. Currently, indium tin oxide (ITO) coated glass is most often used because ITO has relati...

Ca/calmodulin-dependent protein kinases II (CaMKII) have important functions in regulating cardiac excitability and contractility. In the present study, we examined whether CaMKII regulated the transient outward K current (Ito) in whole-cell patch-clamped human atrial myocytes. We found that a specific CaMKII inhibitor, KN-93 (20 mmol/L), but not its inactive analog, KN-92, accelerated the inac...

This book is in copyright. Subject to statutory exception and to the provisions of relevant collective licensing agreements, no reproduction of any part may take place without the written permission of Cambridge University Press. A catalogue record for this book is available from the British Library Library of Congress Cataloguing in Publication data Bouchaud, Jean-Philippe, 1962– Theory of fin...

Indium-tin-oxide (ITO) nanorods (NRs) and nanowhiskers (NWhs) were fabricated by an electron-beam glancing-angle deposition (GLAD) system. These nanomaterials are of interests as transparent conducting electrodes in various devices. Two terahertz (THz) time-domain spectrometers (TDS) with combined spectral coverage from 0.15 to 9.00 THz were used. These allow accurate determination of the optic...

OBJECTIVES The use of indium compounds, especially those of small size, for the production of semiconductors, liquid-crystal panels, etc., has increased recently. However, the role of particle size or the chemical composition of indium compounds in their toxicity and distribution in the body has not been sufficiently investigated. Therefore, the aim of this study was to examine the effects of p...

In the sensorimotor domain, adaptation to distorted sensory input has been well-characterized and is largely attributed to learning mechanisms in the cerebellum that adjust motor output to achieve the same desired sensory outcome. Our interest in the role of the cerebellum in cognitive processes has led us to question whether it also contributes to adaptation in tasks that do not require volunt...