Bronchial asthma (BA) and Allergic rhinitis (AR) are common clinical problems encountered in day to day practice, where inhalational corticosteroids (ICS) or intranasal steroids (INS) are the mainstay of treatment. Iatrogenic Cushing syndrome (CS) is a well known complication of systemic steroid administration. ICS /INS were earlier thought to be safe, but now more and more number of case repor...

In INS/GPS integration, the data fusion algorithm involves properly handling of nonlinear models. Therefore the nonlinear filtering methods have been commonly applied in the INS/GPS integration to estimate the state vector. The most popular and commonly used method is the Extended Kalman Filter (EKF) which approximates the nonlinear state and measurement equations using the first order Taylor s...

Although a USV navigation system is an important application of unmanned systems, combining Inertial Navigation System (INS) with Global Positioning (GPS) can provide reliable and continuous solutions positioning based on its several advantages; the random error characteristics INS instability derived from GPS signal blockage represent potential threat to INS/GPS integration USV. Under this bac...

With its several inherent advantages, an ultra-tightly coupled GPS/INS/PL system will have a dramatic increase in both commercial and defence applications. Integrating the correlator measurements, I (in-phase) and Q (quadrature), with position, velocity and attitude from INS in a Kalman filter characterises this type of system. The Doppler feedback derived from the corrected INS is then fed bac...

Nasopharyngeal carcinoma (NPC) is a multifactoral and polygenic disease with high prevalence in Southeast Asia and Southern China. Environmental factors and genetic susceptibility play important roles in NPC pathogenesis. In the present study, we tested the hypothesis that single nucleotide polymorphisms (SNPs) in nuclear factor-kappa B (NFκB) and its inhibitor (IκBα) conferred consistent risks...

introduction: liver plays a pivotal role in glucose and lipid homeostasis. this study was undertaken to evaluate the effects of l. acanthodes hydro-alcoholic extract administration on the liver functional and histological parameters in hyperglycemic rats. methods: twenty-four male wistar rats were randomly allocated into four groups control, hyperglycemic (stz), hyperglycemic + insulin (stz+ins...

Most antiretroviral medical treatments were developed and tested principally on HIV-1 B nonrecombinant strain, which represents less than 10% of the worldwide HIV-1-infected population. HIV-1 circulating recombinant form CRF02_AG is prevalent in West Africa and is becoming more frequent in other countries. Previous studies suggested that the HIV-1 polymorphisms might be associated to variable s...

Broadening clinical evidence has markedly designated inositol(s) as a common and effective therapeutic approach for PCOS and infertility. Although considerable research has been focused on the use in clinical practice of myo-inositol (myo-ins) and D-chiro-inositol (D-chiro-ins), the two major inositol stereoisomers, less attention has been paid to their bioavailability. Therefore, the aim of th...

The role of AMP-activated protein kinase (AMPK) in pancreatic β-cell apoptosis is still controversial, and the reasons for the discrepancies have not been clarified. In the current study, we observed the effects of two well-known AMPK activators 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) and metformin, on apoptosis in rat insulinoma INS-1E cells, and further explored their possible m...

Although it is widely accepted that sleep must serve an essential biological function, little is known about molecules that underlie sleep regulation. Given that insomnia is a common sleep disorder that disrupts the ability to initiate and maintain restorative sleep, a better understanding of its molecular underpinning may provide crucial insights into sleep regulatory processes. Thus, we creat...