BACKGROUND Intramuscular (i.m.) tramadol increases gastric pH during anaesthesia similar to famotidine. We investigated the antacid analgesic value of a single dose of i.m. tramadol given 1 h before elective Caesarean section performed under general anaesthesia. METHODS Sixty ASA I parturients undergoing elective Caesarean section were included in a randomized double-blind study. The patients...

Despite progress in pain management, chronic non-cancer pain (CNCP) represents still a clinical challenge. The efficacy and safety profile of tramadol make it suitable as a long-term treatment in a variety of CNCP conditions. New once-daily (OD) formulations of tramadol have been marketed in various countries, in order to offer the advantage of a reduced dosing regimen and to improve patients' ...

BACKGROUND AND OBJECTIVES Postoperative pain is still a major complication causing discomfort, especially for children. This study aimed at evaluating the use of analgesics from surgery completion to postoperative intensive care unit (PACU) discharge as a prophylactic or therapeutic approach for children less than 1 year of age. METHODS Based on the Anesthesiology Department files, a retrospe...

There are a few reports of seizure induced by tramadol at therapeutic dose. Two case reports of repeated seizures with following agitation due to treatment with tramadol are presented here. Both of them have similar presentation and tramadol was injected intravenously at therapeutic doses. Tramadol prescription especially intravenously can evoke seizure with agitation or even status epilepticus...

morphine and tramadol which have analgesic effects can be administered acutely or chronically. this study tried to investigate the effect of these drugs at various times by using different methods of administration (intraperitoneal, oral, acute and chronic). sixty adult female rats were divided into six groups. they received saline, morphine or tramadol (20 to 125 mg/kg) daily for 15 days. a ho...

Tramadol has weak opioid properties, and an analgesic effect that is mediated mainly by inhibition of the reuptake of norepinephrine and serotonin (5-hydroxytryptamine [5-HT]) and facilitation of 5-HT release (1,2) at the spinal cord. Because 5-HT3 receptors play a key role in pain transmission at the spinal level (3), the 5-HT3 antagonist ondansetron may decrease the efficacy of tramadol, as s...

Epidural analgesia using local anaesthetic agent is popular simple, effective & economical way of providing postoperative analgesia. In few previous study opioids were added with anaesthetics, so that even small doses can provide profound longer duration less side effects. We compared the efficacy epidural butophanol tramadol as adjuvant bupivacaine, for in view safety profile among opioids...

Background: Prevalence of recurrent shoulder dislocation in patients taking tramadol has not been studiedyet so, this study aims to study the recurrent shoulder dislocation following tramadol induced seizure. Methods: In this cross-sectional study, 205 patients with recurrent shoulder dislocation complaints (2 or more) referred to Shafa Orthopedic and Iranmehr hospitals Tehran, Iran, from Oc...

BACKGROUND We wanted to determine the postoperative analgesic efficacy of preincisional caudal epidural block versus instillation (splash block) following inguinal herniorrhaphy in children. METHODS THIRTY CHILDREN (AGE RANGE: 1-7 years) who were scheduled to undergo inguinal herniorrhaphy were divided into 2 groups: the caudal block group and the splash block group with 15 children in each g...