A life-saving response to hypoglycemia requires rapid sensing of decreases in glycemia and consequent brisk glucagon secretion. Preceding studies have shown that mice lacking glucose transporter type 2 (GLUT2) lose this response. In this issue of the JCI, Marty et al. report that glucose sensing and consequent pancreatic glucagon secretion are restored by re-expression of GLUT2 in glial but not...

In the catabolic state with no food intake, the liver generates ketones by breaking down fatty acids. During the nocturnal fast or longer starvation periods, this protects the brain, which cannot oxidize fatty acids. In 1977, we published a study in the JCI noting the surprising realization that malonyl-CoA, the substrate of fatty acid synthesis, was also an inhibitor of fatty acid oxidation. S...

Division of Pediatric Infectious Diseases and The Research Division of Immunology, Department of Biomedical Sciences, and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, California, USA. Division of Hematology and Oncology, Cedars-Sinai Medical Center, UCLA School of Medici...

The purpose of this study was to determine the optimal portfolio in telecommunications sector listed on Indonesia Stock Exchange based Jakarta Composite Index for period January 2018–December 2020 using Single Model. This type research is an applied research. with secondary data obtained from Exchange, Yahoo Finance, and Bank Indonesia. number samples taken 5 stocks, namely TLKM, ISAT, EXCL, BT...

PT. Kalbe Farma became one of the issuers that during Covid-19 pandemic earned alarge profit per share, so this study aims to see if there is abnormal return and tradingvolume activity around date dividend announcement made by duringthe pandemic. The event method used reaction theIndonesian Capital Market observation period. period carriedout five days before after dividendannouncement Farma. S...

Diabetes results from the absolute or relative deficiency of insulin-producing beta cells. The prospect that non-beta pancreatic cells could be harnessed to become beta cells has led to interest in understanding the plasticity of pancreatic cells. Recent studies, however, have shown that adult beta cells are largely derived from preexisting beta cells. In this issue of the JCI, Desai et al. sho...

Hospitals have many forms of danger due to many different working conditions. Hospital personnel also take risks whilst providing health care which may cause health problems to themselves. The research, related to health and safety of nurses and other staff was carried out in order to compare and determine the occupational health problems and evaluate the occupational safety precautions and app...

This study aims to determine which variabel independent (IHSG, USD exchange, money supply (M2), and inflation) that has the most influence of expected returns using Arbitrage Pricing Theory Model for selected stock issuers from KOMPAS100 Index period 2020 – 2022. The population in this are all registered as members 2022 a purposive sampling technique obtain 57 Data on who is taken doktorsaham.c...

本研究では、ポリマーの種類およびポリマーセメント比の異なるポリマーセメントモルタル（PCM）を結合材として、目標空隙率を変化させたポーラスコンクリートの圧縮および曲げ強度性状と、それらに対する日本コンクリート工学会（JCI）の研究委員会がポーラスコンクリートの強度管理方法として提案している、圧縮および曲げ強度比─空隙率関係を用いた強度推定式の適用性について検討している。その結果、PCMの結合材としての利用は、ポーラスコンクリートの曲げ強度改善に寄与すること、また、各種PCMを結合材としたポーラスコンクリートにおいても、JCIの研究委員会による強度推定式が適用可能であることを明らかにしている。