Türkiye’de 2017 yılında kabul edilen 6771 sayılı Kanunla, uzun süredir uygulanmakta olan Parlamenter Hükümet Sistemi yerini Cumhurbaşkanlığı Sistemine bırakmıştır. sisteminde gerçekleşen bu değişim, Türk Kamu Yönetiminin hem yapılanmasında de işleyişinde oldukça önemli değişikleri beraberinde getirmiştir. Esas olarak merkezi yönetimin başkent teşkilatı üzerinde etkileri hükümet sistemi değişikl...

This study tested susceptibilities of Anopheles minimus mosquitoes to deltamethrin during each of 19 generations (although technical problems excluded selective pressure experiments during generations 11-13). The ultimate goal was to establish a pyrethroid resistant colony of this important malaria vector in Thailand. Resistance was selected for by exposing, using the World Health Organization ...

Purpose of this study was to establish a lecithin nanoemulsion (LNE) without any synthetic surfactant as a topical delivery vehicle and to evaluate its topical delivery potential by the following factors: particle size, morphology, viscosity, stability, skin hydration and skin penetration. Experimental results demonstrated that an increasing concentration of soybean lecithin and glycerol result...

China and ASEAN have been maintaining a relationship both cooperative and competitive in the textile trade. Due to its labor intensive feature and high dependence on foreign trade , the textile trade has received much attention after the 2008 financial crisis. The customs data (classified by the HS code) from year 2006-2009 is employed to research the impact of the crisis on the trade pattern o...

F10 is an oligonucleotide based on the thymidylate synthase (TS) inhibitory 5-fluorouracil (5-FU) metabolite, 5-fluoro-2'-deoxyuridine-5'-O-monophosphate. We sought to determine the activity of F10 against preclinical models of acute lymphoblastic leukemia (ALL). F10 treatment resulted in robust induction of apoptosis that could not be equaled by 100 fold more 5-FU. F10 was more potent than Ara...

The incidence of cancer is constantly increasing. Chemo/radiotherapy is one of major methods of treating cancer. Although adverse chemo/radiotherapy events, such as anemia and neutropenia, can be successfully cured, thrombocytopenia is still problematic. We constructed the Hyper-IL11 (H11) cytokine by linking soluble interleukin 11 receptor alpha (sIL-11Ralpha) with IL-11. In vivo H11 activity ...

Aim/purpose – The purpose of this paper is to analyze regional trade integration 10 Central and Eastern Europe countries (CEE-10) during the 2004-2018 period, identify regional- country-level patterns attribute them potential causes indicated by literature. Design/methodology/approach employed literature-based indicators data on CEE-10 in goods conducted a review empirical studies investigating...

t his paper investigates the gain of bilateral trade between china and u.s. in manufacturing sectors when both countries play a role in asymmetric (biased) growth of  international trade. our model includes a special case of biased growth theory in international trade. we collected labor productivity, export and import data by using classification of manufacturing industries, for u.s. and china...