We use the deformation method for moving grids to construct invertible transformation. We review the existing method by harmonic maps in 2D and discuss the difficulty it encounters in 3d domains. The proposed method is based on a div-curl-ode system, which can be used as constraints for a class of optimization problems. Preliminary numerical results demonstrated the effectiveness of the method....

In recent issues of Drug Discovery Today [1,2], Jurgen Drews and David Cavalla discussed the future productivity of drug discovery. Although they made many insightful and valid comments, I would like to add some points to the overall discussion. My first point is that most small biotechnology companies are not funded enough to enter a Phase III clinical study. Often, it is not even in their bus...

Flanders and served that most Catholic of rulers, Charles V, is not mentioned, although Colombo is given counter-reformation Catholic beliefs because he served the Pope, and Fabricius' religious views are deduced from his friendship with Sarpi and his membership of the Venetian intellectual elite. To his credit, Cunningham is honest in his admission of the theory's weaknesses. He allows that Co...

Consider a deterministic dynamical system in a domain containing a stable equilibrium, e.g., a particle in a potential well. The particle, independent of initial conditions, eventually reaches the bottom of the well. If however, the particle is subjected to white noise, due, e.g., to collisions with a population of smaller, lighter particles comprising the medium through which the particle trav...

Nature 1993;362:801–809. 5. Libby P, Egan D, Skarlatos S. Roles of infectious agents in atherosclerosis and restenosis: an assessment of the evidence and need for future research. Circulation 1997;96:4095–4103. 6. Saikku P, Leinonen M, Mattila K, Ekman MR, Nieminen MS, Makela PH, Huttunan JK, Valtonen V. Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary ar...

You have accessJournal of UrologyProstate Cancer: Localized: Ablative Therapy (MP46)1 Sep 2021MP46-03 PIVOTAL TRIAL OF MRI-GUIDED TRANSURETHRAL ULTRASOUND ABLATION IN MEN WITH LOCALIZED PROSTATE CANCER: THREE-YEAR FOLLOW-UP Laurence Klotz, Christian P. Pavlovich, Joseph Chin, Gencay Hatiboglu, Michael Koch, David Penson, Steven S. Raman, Aytekin Oto, Jurgen Fütterer, Marc Serrallach, James Rell...

Does God react? Can be disappointed? repent? In the 1990s, a heated controversy over God's openness divided evangelical theologians in North America. On one side stood conservative evangelicals who affirmed God’s sovereignty, omniscience, and omnipotence based on traditional doctrines of Calvinist Puritanism. other were thinkers with Pietist, Methodist, or Pentecostal leanings convinced that do...

Rolf Stahl, senior professor at the University Medical Center Hamburg-Eppendorf, passed away unexpectedly on February 25, 2023. Throughout his scientific career, Stahl dedicated efforts toward advancing our understanding of pathogenesis immune-mediated kidney diseases with a particular focus membranous nephropathy. Many discoveries and contributions to field have directly translated improvement...

Introduction: Alcoholic and nonalcoholic fatty livers are highly prevalent in human populations and may develop into steatohepatitis and in some cases into cirrhosis requiring liver transplantation. AMP-activated protein kinase (AMPK) has become as a novel therapeutic target for the treatment of metabolic syndromes. We have isolated a novel AMPK pathway activator cryptotanshinone from Salvia mi...