The NADPH-dependent (S)-carbonyl reductaseII from Candida parapsilosis catalyzes acetophenone to chiral phenylethanol in a very low yield of 3.2%. Site-directed mutagenesis was used to design two mutants Ala220Asp and Glu228Ser, inside or adjacent to the substrate-binding pocket. Both mutations caused a significant enantioselectivity shift toward (R)-phenylethanol in the reduction of acetopheno...

Biological responses often obey Weber's law, according to which the magnitude of the response depends only on the fold change in the external input. In this study, we demonstrate that a system involving a simple autocatalytic reaction shows such a response when a chemical is slowly synthesized by the reaction from a faster influx process. We also show that an autocatalytic reaction process occu...

The well-known third list homomorphism theorem states that if a function h is both an instance of foldr and foldl , it is a list homomorphism. Plenty of previous works devoted to constructing list homomorphisms, however, overlook the fact that proving h is both a foldr and a foldl is often the hardest part which, once done, already provides a useful hint about what the resulting list homomorphi...

The CCAAT box is one of the most common cis-elements present in eukaryotic promoters and is bound by the transcription factor NUCLEAR FACTOR Y (NF-Y). NF-Y is composed of three subunits, NF-YA, NF-YB, and NF-YC. Unlike animals and fungi, plants have significantly expanded the number of genes encoding NF-Y subunits. We provide a comprehensive classification of NF-Y genes, with a separation of cl...

Recently Milovanovic et al. [Bulletin T.CLIII de l?Aca?mie serbe des sciences arts - 2020.] proved that if P(z) ? Pn with no zeros in |z| < k, k 1, then, |P?(z)| ?P?/2 [n {n(k 1/k + 1) 2/k 1 (|c0| kn|cn|/|c0| kn|cn|)} |P(z)|2 ?P?2], = where c0 c1z ... cnzn is a polynomial of degree n. In this paper, we obtain some results concerning the class polynomials having s?fold zero at origin. These n...

Analysis of heart sound signals for automatic segmentation and classification has revealed in recent decades that it the potential to detect pathology accurately clinical applications. Various audio signal processing techniques have been used reduce subjectivity analysis. This study aims classify normal abnormal signals. The feature extraction process was optimized by EMD calculated using five ...

Mitochondrial cholesterol 27-hydroxylase (CYP27A1) plays an important role in the maintenance of intracellular cholesterol homeostasis. Cholesterol delivery to the mitochondrial inner membrane is believed to be a rate-limiting step for the "acidic" pathway of bile acid synthesis. This work reports that proteinase K treatment of mitochondria markedly increases CYP27A1 specific activity. With end...

The exact order of mixing for zero-dimensional algebraic dynamical systems is not entirely understood. Here non-Archimedean norms in function fields of positive characteristic are used to exhibit an asymptotic shape in non-mixing sequences for algebraic Z-actions. This gives a relationship between the order of mixing and the convex hull of the defining polynomial. Using these methods, we show t...

BACKGROUND Variance in microarray studies has been widely discussed as a critical topic on the identification of differentially expressed genes; however, few studies have addressed the influence of estimating variance. METHODOLOGY/PRINCIPAL FINDINGS To break intra- and inter-individual variance in clinical studies down to three levels--technical, anatomic, and individual--we designed experime...

This paper describes XRCE’s participation in Large Scale Visual Concept Detection and Annotation Task [16] and Photo Retrieval Task [17] of ImageCLEF 2009. Those tasks both use a new collection which is different and which is much larger than the ones used in past sessions. Moreover, new kinds of challenge to tackle were designed such as new categories to detect or new types of topic to deal wi...