background: according to some provincial reports, prevalence of hepatitis a has had a decreasing trend during the past decade in iran. we aimed to overview clinical manifestations and laboratory findings of iranian pediatric patients diagnosed with hepatitis a infection. materials and methods: this retrospective study was performed on 162 consecutive pediatric cases of hepatitis a infection. da...

background and objective: chronic renal failure (crf) may have many effects on nervous system and manifest as headache, seizure, dialysis disequilibrium syndrome, cerebral hemorrhage, hypertensive encephalopathy, uremic neuropathy, and some neurologic complications of transplantation. in this present study we investigate neurologic disorders in children with crf. methods: in this descriptive, c...

brucellosis is a major health problem in many parts of the world, particularly in the mediterranean and middle east. very few data on the frequency and diversity of haematological abnormalities occurring in brucellosis have been reported. in the present study 85 patients with brucellosis in imam khomeini hospital during 1997-2002 were investigated retrospectively to determine the haematological...

Background: Hyperbilirubinemia is a common problem in neonates. It is observed during the first week of the life in approximately 60% of term and 80% of preterm neonates. Kernicterus is a rare but serious consequence of undiagnosed hyperbilirubinemia. In this situation, indirect bilirubin deposit in the brain and causes transient dysfunction and occasionally permanent neuronal damage. The aim o...

introduction: wegener granulomatosis is a rare multisystemic disease with an unknown cause, characterized by necrotic granulomatous lesions in respiratory tract, systemic vasculitis in small arteries and veins and necrotizing glomerulonephritis. wegener can affect any organ including kidneys, eyes or other organs but classically affects upper and lower respiratory tract. one of the rare but imp...

inborn errors of organic acid metabolism are relatively recently recognized diseases with a wide spectrum of clinical signs and symptoms: ranging from asymptomatic, normal appearing children to death during first few days of life.in my presentation i will try to explain some of the most common clinical presentation of these disorder with stress on neurologic findings. organic acidemia usually h...

Bilirubin is the end product of degradation of the heme moiety of hemoproteins. Hemoglobin, derived from senescent erythrocytes, is the major source of bilirubin. Significant fractions are also derived from other hemoproteins of liver and other organs. Historically, hyperbilirubinemia has attracted the attention of clinicians as a marker of liver dysfunction. Subsequently, the studies of biliru...

This article is adapted from a published evidence report concerning neonatal hyperbilirubinemia with an added section on the risk of blood exchange transfusion (BET). Based on a summary of multiple case reports that spanned more than 30 years, we conclude that kernicterus, although infrequent, has at least 10% mortality and at least 70% long-term morbidity. It is evident that the preponderance ...