Mutations in the GJB2 gene, which encodes Cx26, are the most common cause of sensorineural deafness. In syndromic cases, such as keratitis-ichthyosis-deafness (KID) syndrome, in which deafness is accompanied by corneal inflammation and hyperkeratotic skin, aberrant hemichannel function has emerged as the leading contributing factor. We found that D50N, the most frequent mutation associated with...

Graphical Abstract “When I was a kid wanted to be honestly scientist … The most challenging part of my job is resisting the urge procrastinate on administrative responsibilities by talking research students. …” Find out more about Wade Petersen in his Introducing Profile.

For any compact Kähler manifold M , the cone of Kählerian in-finitesimal deformations of M , say KID(M), is by definition the subset of H 1 (M, Θ) (the 1 st cohomology of the holomorphic tangent sheaf of M) consisting of those elements in the images of Kodaira-Spencer maps for the germs of complex analytic families (X, M) → (S, 0) such that X carries a Kähler metric. If M is a complex torus of ...

GAP JUNCTIONS PROVIDE A PATHWAY for intercellular communication primarily by directly interconnecting the cytoplasm of adjacent cells (3). This pathway consists of arrays of channels, composed of proteins known as connexins. Connexin channels create a direct conduit enabling diffusion of cytoplasmic molecules, ions, and water between cells. Gap junctions thus coordinate signaling and metabolism...

BACKGROUND Depression in adolescents constitutes a global public health concern. However, data on its prevalence and associated factors are limited in low income countries like Uganda. METHODS Using a cross-sectional descriptive study design, 519 adolescent students in 4 secondary schools in Mukono district, Uganda, were randomly selected after meeting study criteria. The 4 school types were:...

Prenatal stress (stress experienced by a pregnant mother) and its effects on offspring have been comprehensively studied but relatively little research has been done on how prenatal social stress affects farm animals such as goats. Here, we use the operational description of 'stress' as "physical or perceived threats to homeostasis." The aim of this study was to investigate the prenatal effects...

Many applications in cosmology and astrophysics at millimeter wavelengths — CMB polarization, studies of galaxy clusters using the Sunyaev-Zeldovich effect, studies of star formation at high redshift and in our local universe and our galaxy — require large-format arrays of millimeter-wave detectors. Feedhorn, lens-coupled twinslot antenna, and phased-array antenna architectures for receiving mm...