The clinical validation of several anti-angiogenic agents targeting the VEGF pathway for the treatment of metastatic colorectal cancer (Hurwitz et al., 2004), non-small cell lung cancer (Sandler et al., 2006), hepatocellular carcinoma (Llovet et al., 2008) and metastatic renal cell carcinoma (mRCC) (Motzer et al., 2009) has provided evidence that angiogenesis inhibition can lead to increased ov...

The non-linear invariance principle of Mossel, O’Donnell and Oleszkiewicz establishes that if fpx1, . . . , xnq is a multilinear low-degree polynomial with low influences then the distribution of fpB1, . . . ,Bnq is close (in various senses) to the distribution of fpG1, . . . ,Gnq, where Bi PR t ́1, 1u are independent Bernoulli random variables and Gi „ Np0, 1q are independent standard Gaussians...

Introduction The kindlin family of focal adhesion (FA) proteins consists of three evolutionarily conserved proteins, kindlin-1, -2 and -3 [also known as fermitin family homolog 1, 2 and 3 (FERM1, FERM2 and URP2), respectively], and was named after a rare congenital skin disease – the Kindler syndrome – which is caused by mutations in the gene encoding kindlin-1 (Jobard et al., 2003; Siegel et a...

BACKGROUND Fermitin family member 1 (FERMT1, Kindlin-1) is an epithelial-specific regulator of integrin functions and is associated with Kindler syndrome, a genetic disorder characterized by skin blistering, atrophy, and photosensitivity. However, the possible role of kindlin-1 in cancer remains unknown. METHODS Kindlin-1 expression was quantified in several human cancers using quantitative r...

Med 178:669, 1993 7. Caux C, Massacrier C, Vanbervliet B, Dubois B, Van Kooten C, Durand I, Banchereau J: Activation of human dendritic cells through CD40 cross-linking. J Exp Med 180:1263, 1994 8. Aloe L, Bracci-Laudiero L, Bonini S, Manni L: The expanding role of nerve growth factor: From neurotrophic activity to immunologic diseases. Allergy 52:883, 1997 9. Torcia M, Bracci-Laudiero L, Lucib...

sında cerrahinin öneminden daha tartışmalı olan bir kaç konu vardır. Optimum cerrahi prosedürleri ile ilgili farklı görüşlerin olması yanında, bu hastalığın tedavisinde cerrahinin yeri olup olmadığı hakkında temel anlaşmazlıklar da bulunmakta. Ancak birçok göğüs cerrahı da katılacaktir ki, fiilen mezotelyoma hastalarının, gerçek anlamda tam rezeksiyonu mümkün değildir. Ne ekstraplevral pnömonek...

Diaminopimelic acid, which is widely distributed in bacteria, is converted into lysine by a specific decarboxylase (Work & Dewey, 1953; Dewey, Hoare & Work, 1954; Antia, Hoare & Work, 1957), and it has been suggested as an immediate precursor of lysine in some bacteria. A mutant of Escherichia coli deficient in the decarboxylase requires lysine for growth and accumulates diaminopimelic acid in ...

Both drawing and language are fundamental and unique to humans as a species. Just as language is a representational system that uses systematic sounds (or manual/ bodily signs) to express concepts, drawing is a means of graphically expressing concepts. Yet, unlike language, we consider it normal for people not to learn to draw, and consider those who do to be exceptional. Why do we consider dra...

27(5): 672–680. 19. Van Cutsem E, Rivera F, Berry S et al. Safety and efficacy of first-line bevacizumab with FOLFOX, XELOX, FOLFIRI and fluoropyrimidines in metastatic colorectal cancer: the BEAT study. Ann Oncol 2009; 20: 1842–1847. 20. Kozloff M, Yood MU, Berlin J et al. Clinical outcomes associated with bevacizumab-containing treatment of metastatic colorectal cancer: the BRiTE observationa...

Rothmund-Thomson syndrome (RTS) is a genodermatosis presenting with a characteristic facial rash (poikiloderma) associated with short stature, sparse scalp hair, sparse or absent eyelashes and/or eyebrows, juvenile cataracts, skeletal abnormalities, radial ray defects, premature aging and a predisposition to cancer. The prevalence is unknown but around 300 cases have been reported in the litera...