The gastrointestinal (GI) transit and absorption of orally administered theophylline, a highly absorbable drug without presystemic elimination, were investigated under fasted and fed conditions using three rats in a crossover study. To evaluate the GI transit rate for each segment in vivo, a noninvasive technique, gamma scintigraphy, was employed using a nonabsorbable compound, (99m)Tc-labeled ...

One of the main functions of the skin is to control the ingress and egress of water into and out of the body. The transport kinetics of water in the stratum corneum (SC), the dominant site of resistance in the skin, is normally described assuming a homogeneous membrane model. In the present work, the desorption of water from SC was studied and profiles obtained for amount desorbed versus time p...

Three sheep fitted with a ruminal cannula and an abomasal catheter were used to study water kinetics and absorption of VFA infused continuously into the rumen. The effects of changing VFA concentrations in the rumen by shifting VFA infusion rates were investigated in an experiment with a 3 x 3 Latin square design. On experimental days, the animals received the basal infusion rate of VFA (271 mm...

background: dna damage is one of the major consequences of radiation exposure onto the biological systems. a series of compounds including flavanoids were found to render dna protection against radiation damage. in this study we elucidated the potential of rutin and rutin hydrate to protect plasmid dna against damage induced by irradiation. materials and methods: dpph and hydroxyl radical scave...

Coatings are a cheap and efficient solution to protect underlying metallic substrates against electrochemical corrosion. High performance coatings do not only provide this protection of the substrate in the undamaged state but also when they are scratched. This enhanced protection can be achieved in many different ways (ranging from primers based on expansive phases which seal the crack upon sc...