Disease course in melanoma often cannot be accurately predicted by means of the prognostic factors usually considered in patients with melanoma; therefore, new factors are clearly needed. Increasingly robust scientific evidence shows that tumor lymph vessels play a key role in melanoma that metastasizes by lymphatic and hematogenous pathways. We review current knowledge and examine the implicat...

This paper presents a multilevel expert system architecture for the diagnosis, prognosis and monitoring in medicine. These problems are solved with procedural programming (C language) and logical programming (CLIPS language). This double approach allowed a comparison between different methods of implementing an expert system. An important element of this project is an expert system generator, e...

Genomics have allowed important advances in the knowledge of the etiology and pathogenesis of complex disease entities such as acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Genomic medicine aims to personalize and optimize diagnosis, prognosis and treatment by determining the influence of genetic polymorphisms in specific diseases. The scientific community must cope wi...

The importance of cardiac implantable electronic devices (CIEDs) in the treatment rhythm disturbances, heart failure, and prevention sudden death is indisputable. However, CIED therapy associated with complications, among which infections are particularly unfavourable terms prognosis. diagnosis management remain complex, a significant impact on mortality healthcare costs. For these reasons, ris...

Oral lichen planus (OLP) is a relatively common mucosal disease that can present isolated or associated with cutaneous lichen planus. Contrarily to its cutaneous counterpart, though, OLP tends to be chronic, relapsing, and difficult to treat. Severe morbidity is related to erosive forms, and more aggressive presentations have been described, such as the "gingivo-vulvar syndrome". This article r...

Breast Cancer Diagnosis and Prognosis are two medical applications pose a great challenge to the researchers. The use of machine learning and data mining techniques has revolutionized the whole process of breast cancer Diagnosis and Prognosis. Breast Cancer Diagnosis distinguishes benign from malignant breast lumps and Breast Cancer Prognosis predicts when Breast Cancer is likely to recur in pa...

We report a case of unusual presentation of actinomycosis in the tonsil causing massive unilateral enlargement in a 78-year-old female. To our knowledge, only three cases of actinomycosis causing unilateral tonsillar enlargement have previously been published. Since this anaerobic organism is difficult to culture, the diagnosis is made by observing its associated sulfur granules in the biopsy s...

Laryngeal squamous cell carcinoma (SCC) is rare in children. Usually, laryngeal SCC in children has a poor prognosis. A 9-year-old boy is reported who was diagnosed as having poorly differentiated laryngeal squamous cell carcinoma with neck metastasis. This report aims to highlight the importance of a comprehensive knowledge of differential diagnosis, putting great attention to the onset of sym...

Intracerebral hemorrhage as initial presentation of nongestational choriocarcinoma is extremely rare. The therapy includes surgery, chemotherapy and radiotherapy. Nongestational metastatic choriocarcinoma has a poor treatment effect and a dismal prognosis. This study is to report a rare case of intracerebral hemorrhage as initial presentation of unknown primary of nongestational choriocarcinoma...