background: chitosan nanoparticles have become of great interest for nanomedicine, biomedical engineering and development of new therapeutic drug release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity. the aim of the present study is to synthesis and optimization of chitosan nanoparticles for industrial and biomedical applicati...

If a suspension of magnetic micrometer-sized and nanosized particles is subjected to a homogeneous magnetic field, the nanoparticles are attracted to the microparticles and form thick anisotropic halos (clouds) around them. Such clouds can hinder the approach of microparticles and result in effective repulsion between them [M. T. López-López, A. Yu. Zubarev, and G. Bossis, Soft Matter 6, 4346 (...

Magnetic resonance (MR) nano-theranostic hyperthermia uses magnetic nanoparticles to target and accumulate at the lesions and generate heat to kill lesion cells directly through hyperthermia or indirectly through thermal activation and control releasing of drugs. Preclinical and translational applications of MR nano-theranostic hyperthermia are currently limited by a few major theoretical diffi...

A novel magnetic nanoparticle-based electrochemical immunoassay of carcinoembryonic antigen (CEA) was designed as a model using CEA antibody-functionalized magnetic beads [DNA/Fe(3)O(4)/ZrO(2); Fe(3)O(4) (core)/ZrO(2) (shell) nano particles (ZMPs)] as immunosensing probes. To design the immunoassay, the CEA antibody and O-phenylenediamine (OPD) were initially immobilized on a chitosan/nano gold...

The aim of the work is to study pharmacological substances that play a role eNOS expression regulators in modification lead intoxication effects experiment. Materials and methods. In experiment, linear male rats same age were used: intact with (120 heads). design was following: group 1 – control; 2 acetate solution; 3 + L-nitroarginine methyl ester; 4 5 L-arginine; 6 L-arginine. research carrie...

Investigation of the Role L-Arginine and L-NAME in Dorsal Hippocampus on Anxiety, Depression Brain Level BDNF after Stress Male Mice

Development of reliable cell-based nanotoxicology assays is important for evaluation of potentially hazardous engineered nanomaterials. Challenges to producing a reliable assay protocol include working with nanoparticle dispersions and living cell lines, and the potential for nano-related interference effects. Here we demonstrate the use of a 96-well plate design with several measurement contro...

The activation of stimulator interferon genes (STING) in the cytosol by cyclic dinucleotides (CDNs) enhances antitumor immunity through induction proinflammatory cytokines, such as type-I interferons (IFN-I). However, high hydrophilicity and negative charge CDNs hinders their delivery into cells. Here, developing a library cationic polypeptide-modified dendrimers, it is shown that can be effici...

Acute pancreatitis (AP) is a life-unpleasant situation with contradictory and inadequate treatments. In this regard, the present study evaluated effect of possible pretreatment lipase-pancreatin on L-arginine-induced AP. Forty adult mice were selected divided into five groups: I) control group, II III) AP groups (i.p.) receiving L-arginine 2×300 2×400 mg/100 g body weight (b.w.), IV) (2×300 L-a...