نتایج جستجو برای: l1 glossing
تعداد نتایج: 32414 فیلتر نتایج به سال:
L1 neural cell adhesion molecule is the founding member of the L1 subfamily of the immunoglobulin superfamily and plays an important role in the overall development of both the central and peripheral nervous systems, making it an attractive candidate for promoting neural regeneration following injury. Currently, L1 used for experimental studies is primarily mammalian-derived; however, the insec...
L1, a neural cell adhesion molecule of the immunoglobulin superfamily, is involved in neuronal migration and differentiation and axon outgrowth and guidance. Mutations in the human and mouse L1 gene result in similarly severe neurological abnormalities. To dissociate the functional roles of L1 in the adult brain from developmental abnormalities, we have generated a mutant in which the L1 gene i...
Recently we reported that gene codon composition determines differentiation-dependent expression of the PV L1 genes in mouse primary keratinocytes (KCs) in vitro and in vivo (Zhao et al. 2005, Mol. Cell Biol. 25:8643-8655). Here, we investigated whether generalized substitution of isoencoding codons affects the duration of expression of PV L1 genes in mouse and human KCs in day 1 culture transi...
Human Long interspersed element-1 (L1) retrotransposons contain an internal RNA polymerase II promoter within their 5' untranslated region (UTR) and encode two proteins, (ORF1p and ORF2p) required for their mobilization (i.e., retrotransposition). The evolutionary success of L1 relies on the continuous retrotransposition of full-length L1 mRNAs. Previous studies identified functional splice don...
Blockade of the inhibitory PD-1/PD-L1 immune checkpoint axis is a promising cancer treatment. Nonetheless, a significant number of patients and malignancies do not respond to this therapy. To develop a screen for response to PD-1/PD-L1 inhibition, it is critical to develop a non-invasive tool to accurately assess dynamic immune checkpoint expression. Here we evaluated non-invasive SPECT/CT imag...
قضیه ی کملوس در سال 1967 برای فضاهای l1(µ) توسط کملوس مطرح گردید و کاترجی در سال 1970 این قضیه را به فضاهای lpکه (1?p<2) تعمیم داد. لینارد در سال 1993 عکس قضیه ی کملوس را برای زیر مجموعه های محدب از ( l1(µمورد بررسی قرار داد. در سال 1996 بالدر و هس دو تعمیم از قضیه ی کملوس را بیان کردند و در سال 2010 دی و لینارد این قضیه را برای فضاهای تابعی باناخ نیز ثابت کردند. سرانجام قضیه ی کملوس در سال 2...
در این پروژه کمپلکس های جدید روتنیوم [ru(ttp)(l1)cl]pf6 و [ru(ttp)(l2)cl]pf6 با لیگاندهای اورتو- بنزوکینوندیایمین (l1) و 4و5- دیمتیل- اورتو- بنزوکینوندیایمین (l2) سنتز و با طیف سنجیهای الکترونی (uv-vis)، ft- ir و 1hnmr شناسایی شدند. رفتار شیمیایی کمپلکسهای سنتزی نیز با دستگاه ولتامتری چرخهای دنبال شد. نتایج نشان داد که لیگاندهای (l1) و (l2) به فرم بنزوکینوندیایمین، به فلز مرکزی روتن...
This article critically interrogates media coverage of Claus Meyer, Danish gastro-entrepreneur, founder New Nordic Cuisine, and co-founder the restaurant noma. The analyzes how press has constructed Meyer as an exemplary social entrepreneur on a mission to take established agro-industrial interests change ways we produce consume food. We argue that uncritical narratives, positioned little man w...
Human L1 elements are non-LTR retrotransposons that comprise approximately 17% of the human genome. Their 5'-untranslated region (5'-UTR) serves as a promoter for L1 transcription. Now we find that transcription initiation sites are not restricted to nucleotide +1 but vary considerably in both downstream and upstream directions. Transcription initiating upstream explains additional nucleotides ...
Monoclonal antibodies targeting PD-1/PD-L1 signaling pathway have achieved unprecedented success in cancer treatment over the last few years. Atezolizumab is the first PD-L1 monoclonal antibody approved by US FDA for cancer therapy; however the molecular basis of atezolizumab in blocking PD-1/PD-L1 interaction is not fully understood. Here we have solved the crystal structure of PD-L1/atezolizu...
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