A mathematical model for the startup period of a fixed-bed reactor with first-order reaction kinetics, axial dispersion and film mass transfer resistance was formulated and solved analytically using Laplace transform. The solution can be used to correlate or predict the reactant concentration profiles in the effluent of the reactor. The effects of both the Peclet number and Biot number on the e...

Simulation software based on a detailed unstructured model for penicillin production in a fed-batch fermentor has been developed. The model extends the mechanistic model of Bajpai and Reuss by adding input variables such as pH, temperature, aeration rate, agitation power, and feed flow rate of substrate and introducing the CO2 evolution term. The simulation package was then used for monitoring ...