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تعداد نتایج: 16854048 فیلتر نتایج به سال:
Objective: To review the literature regarding efficacy and safety of off-label use apremilast in combination therapies for psoriasis psoriatic arthritis other currently inflammatory dermatoses. Methods: The Medline database was queried all relevant articles published between 2014 2021 using exploded MeSH terms keywords pertaining to following themes: off-label, therapy, biologics, biologic meth...
Since 2004 the United States has collected approximately $8 billion from fraud enforcement actions against pharmaceutical manufacturers accused under the federal False Claims Act of illegally promoting drugs for off-label uses. Using the case of gabapentin (Neurontin), a drug approved for epilepsy but prescribed for a variety of conditions, we sought to determine whether the enforcement action ...
CONTEXT Limited data exist regarding use of drug-eluting stents outside of approved indications in real-world settings. OBJECTIVES To determine the frequency, safety, and effectiveness of drug-eluting stents for off-label (restenosis, bypass graft lesion, long lesions, vessel size outside of information for use recommendation) and untested (left main, ostial, bifurcation, or total occlusion l...
let $g=(v, e)$ be a graph with $p$ vertices and $q$ edges. an emph{acyclic graphoidal cover} of $g$ is a collection $psi$ of paths in $g$ which are internally-disjoint and cover each edge of the graph exactly once. let $f: vrightarrow {1, 2, ldots, p}$ be a bijective labeling of the vertices of $g$. let $uparrow!g_f$ be the directed graph obtained by orienting the...
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