To gain insight into the conformational properties and compaction of megabase-long chromatin molecules, we reconstituted chromatin from T4 phage DNA (165 kb) and recombinant human histone octamers (HO). The unimolecular compaction, induced by divalent Mg2+ or tetravalent spermine4+ cations, studied by single-molecule fluorescence microscopy (FM) and dynamic light scattering (DLS) techniques, re...

Compactions are a vital maintenance mechanism used by datastores based on the log-structured merge-tree to counter the continuous buildup of data files under update-intensive workloads. While compactions help keep read latencies in check over the long run, this comes at the cost of significantly degraded read performance over the course of the compaction itself. In this paper, we offer an in-de...

In this paper, we discuss some novel techniques for modeling sedimentation and compaction using fully unstructured meshes. The numerical modeling of the sedimentation process is a critical part of basin simulation and synthetic stratigraphy modeling. Normally, structured curvilinear meshes are used to represent sedimentary sequences to be deposited during the simulation. Using this approach, 2D...

The histone-like nucleoid structuring protein (H-NS) is a nucleoid-associated protein, which is involved in both gene regulation and DNA compaction. H-NS can bind to DNA in two different ways: in trans, by binding to two separate DNA duplexes, or in cis, by binding to different sites on the same duplex. Based on scanning force microscopy imaging and optical trap-driven unzipping assays, it has ...

BACKGROUND Isolated left ventricular non-compaction (LVNC) is an uncommon disorder characterized by the presence of increased trabeculations and deep intertrabecular recesses. In adults, it has been found that ejection fraction (EF) decreases significantly as non-compaction severity increases. In children however, there are a few data describing the relation between anatomical characteristics o...