The Mouse Genome Database (MGD) focuses on the integration of mapping, homology, polymorphism and molecular data about the laboratory mouse. Detailed descriptions of genes including their chromosomal location, gene function, disease associations, mutant phenotypes, molecular polymorphisms and links to representative sequences including ESTs are integrated within MGD. The association of informat...

XMRV and polytropic MLV-related virus have been controversially associated with chronic fatigue syndrome (CFS). Subsequent reports failed to detect XMRV and MLV-related virus in CFS patients, and the previous results have been interpreted as a massive laboratory contamination by mouse DNA sequences. Among 12 sequential CFS patients, two were positive for XMRV/MLV sequences. In contrast, 40 sele...

Abstract. Change is inherent to time being transient. With the NMR-MOUSE (MObile Universal Surface Explorer) having matured into an established NMR tool for nondestructive testing of materials, this forward-looking retrospective assesses challenges faced when deployed outside a protected laboratory and how its performance quality can be maintained improved operated under adverse conditions in f...

Knowledge about the laboratory mouse (Mus) genome is far more advanced than that of any other experimental mammal (Figure 1). The first mammalian autosomal linkage group was identified in the mouse (Haldane and others 1915). Since 1915, genetic mapping in the mouse has progressed with increasing rapidity each decade, with nearly 25,000 genes and DNA loci (segments) on the current map. This arti...

Kcnk4–1.7 6 1.0–Adra2c. Additional comments: We have compared our interspecific map of chromosome 5 with a composite mouse linkage map that reports the map locations of many uncloned mouse mutations (provided from the Mouse Genome Database, a computerized database maintained at The Jackson Laboratory, Bar Harbor, ME). Kcnk4 mapped in a region of the composite map that lacks mouse mutations with...

Mouse sperm produce enough ATP to sustain motility by anaerobic glycolysis and respiration. However, previous studies indicated that an active glycolytic pathway is required to achieve normal sperm function and identified glycolysis as the main source of ATP to fuel the motility of mouse sperm. All the available evidence has been gathered from the studies performed using the laboratory mouse. H...

The in-bred laboratory mouse (hereafter referred to as simply mouse) has in the past decades emerged as the go-to animal model in the arena of cardiovascular research. The reasons are straightforward: the relative ease of genetic manipulation coupled with short gestation times, the much cheaper cost of maintaining large numbers, and a large number of similarities to human genomics, proteomics, ...

The vast majority of studies on mouse behavior are performed on laboratory mouse strains (Mus laboratorius), while studies of wild-mouse behavior are relatively rare. An interesting question is the relationship between the phenotypes of M. laboratorius and the phenotypes of their wild ancestors. It is commonly believed, often in the absence of hard evidence, that the behavior of wild mice excee...

background: when male animals die, spermatozoa within the body of animal will be degenerated. because of unique chromatin structure of sperm, maybe this degeneration is different from other cells. however there is not any research which considered directly the integrity of sperm dna by keeping the cadaver in refrigerator. objective: the aim of this study was to assess viability, total motility ...

Inbred mice are an essential animal strain for research as they can improve the reproducibility and reliability of study results. The establishment of new inbred lines is continuing, and new inbred lines are being used in many research fields. C57BL/6 is a mouse laboratory animal that has been developed and used as an inbred strain since early stage of mouse strain development, and, in the 1950...