BACKGROUND Sjögren's syndrome is an autoimmune syndrome involving the exocrine glands specially the salivary and lacrimal glands leading to xerostomia and xerophtalmia. This paper presents a case with primary Sjögren's syndrome that severe dental caries were the first clinical manifestation. CASE PRESENTATION A 42-year-old man was referred to the School of Dentistry, Tehran University of Medi...

Sjögren's syndrome is an autoimmune disease characterized by an autoimmune exocrinopathy involving mainly salivary and lacrimal glands. The histopathological hallmark is periductal lymphocytic infiltration of the exocrine glands, resulting in loss of their secretory function. Several systemic manifestations may be found in patients with Sjögren's syndrome including neurological disorders. Neuro...

logical findings of IgG4-related disease irrespective of the organ of origin. However, hyalinized dense fibrosis as observed in cases 1 and 2 is not typical for IgG4-related diseases to our knowledge. We speculated that this difference might depend on anatomical characteristics of the lacrimal gland (eg, tightly surrounded by muscles and bone) or the duration of this disease. In addition, it is...

Introduction: 18F-Choline PET-CT is an increasingly used technique in patients with prostate cancer. The main indication is to localise the disease in patients with biochemical recurrence. To accurately interpret 18F-Choline PET, knowledge of normal tracer distribution is paramount. The aim of this study was to describe the normal distribution pattern of 18F-Cho...

The existence of a motor innervation to the secretory and myoepithelial elements of salivary glands has been supported amply by physiological and pharmacological studies extending over a century (reviewed in Babkin, 1950 ; Emmelin, 1967) . However, the exact morphological nature of this innervation at the acinar level is less well established, and has been the subject of several conflicting rep...

PURPOSE To show the presence and forms of sialomucin complex (rat Muc4) and receptor tyrosine kinase ErbBs in the rat lacrimal gland and analyze for complexes of ErbB2 and its ligand Muc4. METHODS Northern blot analyses were used to identify sialomucin complex/Muc4 (SMC/Muc4) mRNA in rat lacrimal gland. Immunoblot analyses were performed to detect SMC/Muc4 and ErbBs. Sequential immunoprecipit...

Idiopathic canine keratoconjunctivitis sicca (iKCS) is a common condition of the canine eye involving a deficiency in aqueous tear production which is commonly held to have an immune-mediated, as most probably an autoimmune aetiopathogenesis. Yet to date no direct evaluation has been made of the inflammatory cell populations in the lacrimal tissue of dogs with iKCS. Here we sought to quantify T...

AN aberrant lacrimal gland is an unusual congenital and developmental abnormality. The clinical picture differs from that of an ectopic lacrimal gland, because in the aberrant forms, the main lacrimal gland is in its place and the other gland is additional. In ectopia, the original lacrimal gland is considered to have luxated, and this is not as rare as the appearance of aberrant tissue (Duke-E...

Sex steroid deficiency has been linked to the development and/or progression of a wide variety of clinical disorders, including cardiovascular disease, osteoporosis, obesity, insulin resistance and certain cancers. We hypothesize that sex steroid deficiency specifically that of androgens, may also be a critical pathogenetic factor in the etiology of dry eye syndromes. Dry eye syndromes are a le...

Introduction Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease that affects the function of exocrine glands, such as lacrimal and salivary glands. Extraglandular lesions malignant lymphoma also occur during progressive stage pSS. We have, herein, focused on pulmonary pSS have aimed clarifying their pathophysiological mechanism by comparing glandular with extraglandular observed ...