INTRODUCTION Blood acidification by lactic acid infusion converts bicarbonate to CO2. This effect can be exploited to increase the transmembrane PCO2 gradient of an extracorporeal membrane lung, resulting in a significant increase of extracorporeal CO2 removal. Lactic acid, however, is an energetic substrate and its metabolism might increase total body CO2 production (VCO2), limiting the potent...

Bacterial vaginosis is a prevalent state of dysbiosis of the vaginal microbiota with wide-ranging impact on human reproductive health. Based on recent insights in community ecology of the vaginal microbiome, we hypothesize that sustained vaginal DL-lactic acid enrichment will enhance the recruitment of lactobacilli, while counteracting bacterial vaginosis-associated bacteria. We therefore aimed...

KINNERSLEY AND PETERS [1929, 1930] have demonstrated that there is an increase in the lactic acid content of the brain of the pigeon in polyneuritis (induced by feeding on polished rice) and that the increase is particularly marked in the midand hind-brain. They were inclined to interpret their results as an indication that a local defect in the metabolism of this lower part of the brain was re...

For quantities of lactic acid greater than 10 or 20 mg. the titration method of von Ftirth and Charnass (1) is available. For much smaller quantities, the only methods hitherto proposed have been calorimetric (2). With the disadvantages of calorimetric methods in mind, study was made of a titration method which gives satisfactory results with as little lactic acid as 0.2 mg. Chemical methods fo...

Metformin is a safe drug when correctly used in properly selected patients. In real life, however, associated lactic acidosis has been repeatedly, although rarely, reported. The term metformin-induced lactic acidosis refers to cases that cannot be explained by any major risk factor other than drug accumulation, usually due to renal failure. Treatment consists of vital function support and drug ...

Skeletal muscle is the major producer of lactic acid in the body, but its oxidative fibers also use lactic acid as a respiratory fuel. Monocarboxylate transporter (MCT) 1 has been suggested to play a major role in influx of L-lactic acid for oxidation. The regulation mechanism of MCT1 was characterized utilizing rhabdomyosarcoma cells as an in vitro skeletal muscle model. The uptake of L-lactic...

For quantities of lactic acid greater than 10 or 20 mg. the titration method of von Ftirth and Charnass (1) is available. For much smaller quantities, the only methods hitherto proposed have been calorimetric (2). With the disadvantages of calorimetric methods in mind, study was made of a titration method which gives satisfactory results with as little lactic acid as 0.2 mg. Chemical methods fo...

Lactic acidosis is defined as increase in blood lactate levels in association with acidemia. It should be suspected in all patients presenting with shock & decreased mayocardial contractility. The patients with lactic acidosis have high mortality. However, the prognosis and case fatality are completely dependent on underlying disease in each patient with lactic acidosis being an independent ind...

For quantities of lactic acid greater than 10 or 20 mg. the titration method of von Ftirth and Charnass (1) is available. For much smaller quantities, the only methods hitherto proposed have been calorimetric (2). With the disadvantages of calorimetric methods in mind, study was made of a titration method which gives satisfactory results with as little lactic acid as 0.2 mg. Chemical methods fo...

anti-microbial effects of the lactic acid bacteria have been studied and proved in various investigations. this investigation aimed to study the anti-yeast effect of two isolated lactic acid bacteria species from “chal” (a product from yogurt) as biological preservatives in doogh. to do so, anti-yeast activity of l. brevis and e. faecium against saccharomyces cerevisiae, kluyveromyces. marxianu...