If a dot is flashed in perfect alignment with a pair of dots rotating around the visual fixation point, most observers perceive the rotating dots as being ahead of the flashing dot (flash-lag effect). This perceptual effect has been interpreted to result from the perceptual extrapolation of the moving dots, the differential visual latencies between flashing and moving stimuli, as well as the mo...

OBJECTIVE To determine whether doses of the pineal hormone melatonin alleviate jet lag. DESIGN Double blind, placebo controlled crossover trial. SETTING Long haul return flights from Auckland, New Zealand, to London and back. SUBJECTS Twenty volunteers with experience of transcontinental flights (eight women and 12 men aged 28 to 68). INTERVENTIONS Melatonin (or placebo) 5 mg three days...

For the implementation of time-critical decision support algorithms a precise relation between intervention and effect needs to be established. We evaluated for catecholamines and infusions the relation in time between charted dose and effect on hemodynamic variables. The onset of the change of the hemodynamic variables was determined by autoregressive models. The lag of 13 min (0 29) between i...

In order to comply with the consumer demand for ready-to-eat and look 'fresh' products, mild heat treatment will be used more and more in the agrofood industry. Nonetheless there is no tool to define the most appropriate mild heat treatment. In order to build this tool, it is necessary to study and describe the response of a bacterial population to a mild increase in temperature, from the dynam...

In 1958 MacKay showed that a rigidly moving object becomes visually fragmented when part of it is continuously visible but the rest is illuminated intermittently. For example, the glowing tip of a lit cigarette moving under stroboscopic illumination appeared to move ahead of the intermittently lit body. Latterly rediscovered as "the flash-lag effect" (FLE), this illusion now is typically demons...

The apparent lagging of a short flash in the relation to a moving object, the flash-lag effect (FLE), has so far been measured mainly in terms of illusory spatial offset. We propose a method of measuring the perceived temporal asynchrony of the FLE separately from its perceived spatial offset. We presented a moving stimulus that changed its colour at a certain moment. The observer indicated, in...

In the flash-lag effect (FLE), a flashing object appears to lag behind a moving object when both happen to be physically aligned to each other. According to an earlier account of the FLE (Baldo and Klein 1995 Nature 378 565-566), this perceptual phenomenon would result from differential delays in the perceptual processing of moving and flashing stimuli, presumably involving attentional mechanis...

Tablet in tablet formulation, containing Aceclofenac (API) in core tablet and coated with hydroxylpropyl cellulose (HPC) was evaluated for time drug release with predetermined lag time and subsequent rapid release phase. Various types of press coated tablets were prepared using single punch tablet machine. They were evaluated for various physicochemical properties and in vitro dissolution study...