Liposomes are phospholipid nanoparticles used for targeted drug delivery. This study aimed to determine whether intravenous liposomes accumulate in lamellar tissue during laminitis development in horses so as to assess their potential for targeted lamellar drug delivery. Polyethylene-glycol (PEG) coated liposomes were prepared according to the film hydration method and labelled using (99m)Tc-he...

INDICATIONS for lamellar corneal grafts are somewhat more numerous than those for penetrating keratoplasty, and Paufique, Sourdille, and Offret (1948) mention, besides the usual optical reason for replacing a corneal scar, tectonic, preparatory, aesthetic, and therapeutic indications. This last, designed to interrupt the course of chronic and recurrent corneal disorders, is of peculiar interest...

The movement of cells in small groups, or clusters, was studied in vitro using epithelioid cells from Gordon-Kosswig melanomas (from poecelid fish) and time-lapse cinemicrography. Tumour explants cultured on glass yield cell sheets from which groups of cells separate and become independently motile clusters. These clusters typically contain 3-30 cells, but may have as many as 50. They propel th...

Rab3D is a small GTP-binding protein associated with secretory vesicles in various exocrine and endocrine cells, where it has been implicated in regulated exocytosis. Data obtained previously in pancreas have suggested that rab3D is involved in the coating of secretory granules with filamentous actin. In the present study we employed Western blot analysis, immunofluorescence, and immunoelectron...

PURPOSE Assess the lamellar organisation of the peripheral and central stroma of the keratoconus (KC) and normal cornea. METHODS Five normal and three KC corneas were fixed in 2.5% glutaraldehyde and processed for electron microscopy. The ultrathin sections were observed under JEOL 1400 TEM, and digital images were taken with a bottom-mounted 11-megapixel Quamisa camera, using the iTEM softwa...

Recent morphologic studies of adult mammalian thoracic and abdominal aortic segments have shown that the adult human abdominal aorta deviates significantly from the usual pattern of medial lamellar architecture. In the present study medial growth of these two aortic segments from prenatal life to adulthood was compared in terms of medial architecture and calculated tangential tension levels. Du...

A cytoplasmic structure exhibiting a peculiar configuration of agranular reticulum has been found in the rat pinealocyte, and has been designated a canaliculate lamellar body. It consists of a number of fenestrated, flat cisternae which are closely spaced. They bear some distant resemblance to the annulate lamellae previously reported in a variety of cell types. Profiles of stacks of lamellae i...

The permeability barrier is required for terrestrial life and is localized to the stratum corneum, where extracellular lipid membranes inhibit water movement. The lipids that constitute the extracellular matrix have a unique composition and are 50% ceramides, 25% cholesterol, and 15% free fatty acids. Essential fatty acid deficiency results in abnormalities in stratum corneum structure function...

Lamellar ichthyosis (LI) is a rare genetic disorder with autosomal recessive inheritance. It is equally seen in both sexes and usually manifests at birth. The child presents as a collodion baby. The erythema is minimal or absent; but when present, it is maximum on the face. The scaling is generalized, accentuated on lower extremities and flexural areas. Rickets is a condition in which there is ...

Over the last decade there has been a paradigm shift from penetrating keratoplasty (PKP) to lamellar keratoplasty for the management of primary as well as acquired corneal ectasia. Several treatment modalities have emerged including collagen cross-linking, intrastromal implants, laser vision correction, and recent techniques in central and peripheral lamellar keratoplasty. This article reviews ...