Alzheimer's disease (AD) has been described in the literature, to be associated with impairment of executive function which develops early in the course of disease, and an effective treatment for this clinical feature remains elusive. Preclinical studies have implied that lamotrigine, an antiepileptic agent, could be a potential treatment for executive dysfunction in AD patients. Although there...

objective neurodevelopmental disability is one of the most common problems of children referred to  pediatric neurology clinics. these children may suffer from speech delay, intellectual deficiency and behavioral disorder. some patients with neurodevelopomental delay, especially those with intellectual disability and speech problems, have abnormal electroencephalograms, without clinical seizure...

Lamotrigine is an anticonvulsant and has an antiglutamatergic action, which may contribute to its antidepressant effects, since glutamate has been linked to depression. The purpose of the present study was to investigate the behavioral and molecular effects of lamotrigine treatment in maternally deprived rats. To this aim, deprived and non-deprived male rats were treated with lamotrigine (20 mg...

A wide variety of movement disorders can be induced by the administration of antiepileptic drugs. A 44-year-old female was admitted with involuntary excessive eye blinking that manifested 5 months after beginning the administration of lamotrigine for control of complex partial and secondarily generalized seizures. The involuntary eye blinking persisted while taking lamotrigine, and disappeared ...

A 55-year-old female with no physical problems was initially hospitalized for psychotic mania but soon discharged. A month later she was rehospitalized for bipolar depression and treated with lamotrigine (25 mg/day), olanzapine (10 mg/day), and lorazepam (0.5 mg/day). On day 22, lamotrigine was stopped because of neutropenia. On the same day, the patient developed skin rashes with pruritus, whi...

BACKGROUND Clozapine is the treatment of choice for medication refractory psychosis, but it does not benefit half of those put on it. There are numerous studies of potential post-clozapine strategies, but little data to guide the order of such treatment in this common clinical challenge. We describe a naturalistic observational study in 153 patients treated by a specialist psychosis service to ...

Stevens-Johnsons Syndrome (SJS) is an immune-complex-mediated hypersensitivity reaction and has been linked as an adverse side effects to many drugs. Lamotrigine, an anticonvulsive medication and also a commonly used mood stabiliser, can be associated with this adverse reaction. Although this has not been reported very commonly , SJS has high mortality and morbidity and requires careful attenti...

Lamotrigine is an antiepileptic drug widely used to control seizures. It has many adverse events but in rare instances, it can cause hypersensitivity syndrome (DHS). We describe a case of lamotrigine induced characterized by febrile erythema and eosinophilia. The suspect was replaced valproate leading marked improvement.

Pharmacovigilance presents many challenges, particularly when managing unpredictable, rare conditions, eg, severe cutaneous adverse reactions (SCARs). Such rare events are often only detected from spontaneous reports, which present their own limitations, particularly during a prolonged global launch schedule. GlaxoSmithKline's routine pharmacovigilance includes regular reviews of global adverse...