نتایج جستجو برای: lcn2
تعداد نتایج: 526 فیلتر نتایج به سال:
Objetivo: relatar a atuação fisioterapêutica na lipofuscinose ceróide neuronal tipo 2 infantil tardia. Metodologia: relato de experiência, prospectivo, longitudinal caráter qualitativo, desenvolvido partir da vivência prática do estágio supervisionado obrigatório em Fisioterapia Neurofuncional, quinto ano curso Universidade Estado Pará (UEPA) realizado Unidade Ensino e Assistência Terapia Ocupa...
Abstract Background and Aims Renal operational tolerance is a rare beneficial state of prolonged renal allograft function in the absence immunosuppression. The underlying mechanisms are unknown. We hypothesized that might be driven by inherited protein coding genetic variants with large effect, at least some patients. Method set up European survey over 218,000 transplant recipients collected DN...
Neutrophil gelatinase-associated lipocalin (Ngal, 24p3, SIP24, lipocalin 2, or siderocalin) was originally purified from neutrophils, but with unknown function. Recently, it was identified that Ngal activates nephron formation in the embryonic kidney, is rapidly and massively induced in renal failure and possesses kidney-protective activity. We would like to propose that blood, urine, and kidne...
Abstract BACKGROUND & AIMS Glutamate carboxypeptidase II (GCPII) is elevated in active inflamed biopsies of both Crohn’s disease and ulcerative colitis patients a promising therapeutic target for the treatment IBD. We have previously presented development characterization first-in-class, gut-restricted, orally GCPII inhibitor, (S)-IBD3540, shown that oral (S)-IBD3540 attenuates severity mul...
Biomolecular reagents that enable the specific molecular recognition of proteins play a crucial role in basic research as well as medicine. Up to now, antibodies (immunoglobulins) have been widely used for this purpose. Their predominant feature is the vast repertoire of antigen-binding sites that arise from a set of 6 hypervariable loops. However, antibodies suffer from practical disadvantages...
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