In this study, oxidative energy metabolism was determined in 5 captive bottlenose dolphins (Tursiops truncatus), and subsequently compared to 6 Thoroughbred riding horses, and 12 lactating Holstein cows in order to assess symmorphosis of each animal species. Plasma metabolites profile, plasma MDH (M) and LDH (L) activities, M/L ratio, and plasma LDH isoenzyme distribution patterns were all exam...

Metabolism is an important differentiating feature of cancer cells. Lactate dehydrogenases (LDH) A/B are metabolically important proteins and are involved in the critical step of inter-conversion of lactate to pyruvate. Panepoxydone (PP), a natural NF-kB inhibitor, significantly reduces the oxygen consumption and lactate production of MCF-7 and triple negative (MDA-MB-231, MDA-MB-468 and MDA-MB...

OBJECTIVE Layered double hydroxide (LDH) nanoparticles have been studied as cellular delivery carriers for anionic anticancer agents. As MTX and 5-FU are clinically utilized anticancer drugs in combination therapy, we aimed to enhance the therapeutic performance with the help of LDH nanoparticles. METHOD Anticancer drugs, MTX and 5-FU, and their combination, were incorporated into LDH by reco...

Two kinds of layered double hydroxides (LDHs), MgAl-NO2 (N-LDH) and MgAl-CO3 (C-LDH), were incorporated to study the durability mortar concrete. The LDH contents 1%, 2%, 4% by mass concrete 0.5%, 4%, respectively. effect LDHs on sulfate resistance was studied through dry-wetting cycle test, compressive strength flexural test. In addition, effects pore structure, chloride resistance, carbonation...

INTRODUCTION Lactate dehydrogenase (LDH) activity was assayed in the sera of 76 adult male and 76 adult female patients within the age group of 18-40 years presenting with acute, uncomplicated Plasmodium falciparum malaria infection and a control group of 80 healthy adults within the same age group. METHODS Patient selection and pre-qualification were done by simple random sampling of individ...

Background: Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma and its advanced-stage (MF; stage IIB to IV)) has aggressive behavior. Lactate dehydrogenase (LDH) has been demonstrated to correlate with progression of malignancy specially lymphoma and leukemia. The LDH level is expected to be useful clinical tool for evaluating the progression of MF. Objective: This study aimed ...

Two ethylnitrosourea-induced heterozygous mouse mutants with approximately 58 and 50% of wild-type lactate dehydrogenase (LDH) activity and a gamma-ray-induced heterozygous mutant with 50% of wild-type LDH activity in blood, liver and spleen (expressing predominantly the Ldh-1 gene) were recovered in mutagenicity experiments following spermatogonial treatment. Physiological and genetic studies ...

BACKGROUND Early recognition of disease progression in low-risk myelodysplastic syndromes (MDS) is an important decision point concerning intensive therapies. In a screen program searching for dynamic prognostic determinants, we have identified lactate dehydrogenase (LDH) as a most suitable follow-up parameter. PATIENTS AND METHODS LDH levels were serially determined in 221 patients with de n...

The DNA sequence of the gene encoding the early and specific immunogenic protein P36 of Mycoplasma hyopneumoniae has been determined. Comparison of the DNA sequence and the deduced amino acid sequence of P36 with known genes and proteins in data banks indicated that P36 is a L-lactate dehydrogenase (LDH) (EC 1.1.1.27). Biochemical analysis of protein P36 expressed from the cloned gene in Escher...

Lactate dehydrogenase (LDH), the terminal enzyme of anaerobic glycolysis, plays a crucial role both in sustaining glycolytic ATP production under oxygen-limiting conditions and in facilitating the catabolism of accumulated lactate when stress conditions are relieved. In this study, the effects on LDH of in vivo freezing and dehydration stresses (both of which impose hypoxia/anoxia stress on tis...