The aim of the work is to study pharmacological substances that play a role eNOS expression regulators in modification lead intoxication effects experiment. Materials and methods. In experiment, linear male rats same age were used: intact with (120 heads). design was following: group 1 – control; 2 acetate solution; 3 + L-nitroarginine methyl ester; 4 5 L-arginine; 6 L-arginine. research carrie...

The effects of injection of BAL on the metabolism of lead has been studied by Eagle (1948) and by Ginsburg and Weatherall (1948) in animals poisoned with lead acetate, and by Ryder, Cholak, and Kehoe (1947) in human cases of acute lead poisoning. The action ofBAL has been shown to be the same both in experimental animals and in man; in animals it had no demonstrably protective action, and on oc...

Oxidative damage associated with lead in the brain has been proposed as a possible mechanism of lead toxicity. Of the many antioxidant enzymes, phospholipid hydroperoxidase glutathione peroxidase (PHGPx) is known to protect cells from lipid peroxide-mediated damage by catalyzing lipid peroxide reduction. In this study, the effects of lead on the activity and expression of PHGPx mRNA were invest...

Even though the toxic effects of lead compounds had been studied over many years, inconsistent results have been obtained about their oxidative stress in the testes of adult rats. Lead acetate (20 mg/kg) alters the histology of testes as well as enhances lipid peroxidation and nitric oxide production in both serum and testes with concomitant reduction in glutathione (GSH) and antioxidant enzyme...

Lead, because of its low melting point, was one of the first metals used by man. It was probably isolated soon after the ancients discovered the use of fire. Archeological discoveries indicate the presence of lead objects and pigments during the early Bronze Age. In ancient Egyptian and Greco-Roman times metallic lead was produced as a by-product of silver mining. Extensive evidence of ancient ...