The electrochemical behaviour of lead electrode in hydrochloride solution containing variousoxo-anions at different concentrations was studied by using of cyclic voltammetry (CV) method.Results obtained show that the addition of these inorganic compounds decreases the anodic andcathodic currents peaks according to the following order: H2PO4- > HPO42-> SO42-. It’s revealedalso that the cathodic ...

Recently, cardiovascular disease, also known as loop circulatory system diseases or disorders, is one of the serious diseases including heart disease, stroke, atherosclerosis, myocardial infarction, hypertension, hypotension, and thrombosis. Human pregnane X receptor, PXR, plays a crucial role in exogenous and endobiotic metabolism for rabbit, rat, mouse, and human. The PXR activation can prote...

Gaucher disease (GD), the most common lysosomal storage disorder, results from the inherited deficiency of the lysosomal enzyme glucocerebrosidase (GCase). Previously, wildtype GCase was used for high throughput screening (HTS) of large collections of compounds to identify small molecule chaperones that could be developed as new therapies for GD. However, the compounds identified from HTS usual...

inorganic lead compounds are used most widely in paint and pigment industries. because of exposure to lead dust in workers in a copying center, we compared blood lead levels in these workers to normal individuals and investigated the relationship between job tenures of the workers and their blood lead levels. this survey was performed on 20 simple workers in a copying center of tehran universit...

micrornas (mirnas) are non-coding small rna molecules with 21–25 nucleotides. it plays significant role in control of gene expression at posttranscriptional/translational level. they are commonly dysregulated in human cancers, whereas they may behave either as oncogenes or as tumor-suppressor genes. both genetic and epigenetic events in deregulation of mirna can lead to cancer development. gene...

in this study synthesis of nicotinoyl hydrazone derivatives is investigated by introducing the nicotinicacidhydrazidepharmacophore into several molecules and screening for antimycobacterial activity. benzaldehyde derivatives react with nicotinicacidhydrazideto form nicotinoylhydrazones.the synthesized compounds were screened against m. tuberculosis h 37 rv, clinical isolates of m. tuberculosis ...

Modern drug discovery efforts rely, to a large extent, on lead compounds from two classes of small organic molecules; namely, natural products (i.e., secondary metabolites) and designed compounds (i.e., synthetic molecules). In this article, we demonstrate how these two domains of lead compounds can be merged through total synthesis and molecular design of analogs patterned after the targeted n...

OBJECTIVES There is an urgent need to develop a safe, effective, orally active, and inexpensive therapy for African trypanosomiasis due to the drawbacks of current drugs. Selective tubulin inhibitors have the potential to be promising drug candidates for the treatment of this disease, which is based on the tubulin protein structural difference between mammalian and trypanosome cells. We propose...

A new series of 5-(indole-2-yl)-3-substituted 1,2,4-oxadiazoles were synthesized and evaluated for their anticancer activities. Structures of the compounds were confirmed by spectroscopic methods. Structural modifications were done to improve the antiproliferative activity of compound 1. The results indicated that a benzyloxyl substituent on the C-4 position was better than a methyl substituent...