left bundle branch block

Interruption of anterior fibers of the left bundle branch system together with right bundle branch block was accomplished experimentally in canine and primate hearts. In both species the electrocardiographic effects included a major alteration of the mean electrical axis to a superior and anterior direction. Epicardial excitation was markedly delayed anteriorly, causing widening of the QRS comp...

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Systolic improvement and mechanical resynchronization does not require electrical synchrony in the dilated failing heart with left bundle-branch block.

Journal: :Circulation 2002

Christophe Leclercq Owen Faris Richard Tunin Jennifer Johnson Ritsuchi Kato Frank Evans Julio Spinelli Henry Halperin Elliot McVeigh David A Kass

BACKGROUND Biventricular (BiV) and left ventricular (LV) pacing similarly augment systolic function in left bundle-branch block (LBBB)-failing hearts despite different electrical activation. We tested whether electrical synchrony is required to achieve mechanical synchronization and functional benefit from pacing. METHODS AND RESULTS Epicardial mapping, tagged MRI, and hemodynamics were obtai...

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