Several advances in dialysis therapies have been made. Still, the mortality in end-stage renal disease (ESRD) remains high at rates exceeding 15%. Cardiovascular disease from heart failure or sudden death remains an important cause for mortality in these groups. The most common cardiac anomaly in ESRD is cardiac hypertrophy and this has been observed in 75% of patients at the time of starting d...

Partial correction of anemia in patients with chronic kidney disease (CKD) reduces left ventricular hypertrophy (LVH), which is a risk factor for cardiovascular (CV) morbidity, but complete correction of anemia does not improve CV outcomes. Whether LV geometry associates with CV events in patients who are treated to different hemoglobin (Hb) targets is unknown. One of the larger trials to study...

BACKGROUND Determination of left ventricular hypertrophy (LVH) via electrocardiogram (ECG) is a known independent risk factor for cardiovascular morbidity and mortality in hypertension (HTN). Dietary sodium and HTN are both associated with unfavorable alterations in left ventricular mass, however, to what extent their interplay affects ECG screening for LVH is unclear. METHODS The effects of ...

Background: The present study was conducted to determine the sensitivity and specificity of electrocardiographic criteria for the assessment of left ventricular hypertrophy by comparing it with the gold standard of echocardiography. Methods: Fifty clinically diagnosed patients of LVH were included in this collaborative study of Dept. of Physiology, Army Medical College, Rawalpindi and Departmen...

eNOS (endothelial NO synthase) plays a critical role in the development of ventricular remodelling and cardiac hypertrophy. The purpose of the present study was to determine whether three common variants in NOS3 (the eNOS gene) are associated with the risk of LVH [LV (left ventricular) hypertrophy] in patients with essential hypertension. Three NOS3 genetic variants, -T786C (rs2070744), eNOS4a/...

Hypertensive cardiac remodeling, characterized by left ventricular hypertrophy (LVH) and increased fibrosis, increases the workload of the heart and is a significant risk factor for cardiovascular morbidity and mortality.1 There is a continuous relationship between left ventricular mass and the likelihood of cardiovascular events, including stroke, heart failure, and coronary artery disease, le...

INTRODUCTION 24-hour ambulatory blood pressure (BP) monitoring is a well-validated tool that can reveal the patient's nocturnal dipping pattern. However, to the best of our knowledge, the role of home BP monitoring in identifying nocturnal dipping has not been studied. METHODS We evaluated the nocturnal BP of 30 treatment-naive subjects using a home BP monitoring device. BP measurements were ...

BACKGROUND Left ventricular hypertrophy (LVH) is prevalent in patients with type 2 diabetes mellitus (T2DM). Recent studies show that an increase in albumin-adjusted serum calcium level is associated with an elevated risk of T2DM. We speculate that increased serum calcium levels in T2DM patients are related to LVH prevalence. METHODS In this echocardiographic study, 833 normocalcemia and norm...

We performed a cross-sectional study to evaluate the association of anemia with diastolic dysfunction and left ventricular hypertrophy (LVH) in outpatients who had coronary artery disease. Logistic regression was used to examine the association of blood hemoglobin (Hb) concentrations with diastolic dysfunction and LVH in 822 participants in the Heart and Soul Study who had normal sinus rhythm a...

Electrocardiogram (ECG)is widely used for detection of left ventricular hypertrophy (LVH). For the detection of LVH several different criteria have been used. These criteria have different sensitivity and selectivity, which widely varies from 22% to 54% sensitivity and 100%to 85%specificity respectively. Different LVH criteria has different results of LVH. The aim of the present study was to de...