Purpose To report an innovative technique of interstitial brachytherapy developed for treatment of orbital soft tissue tumors. Material and methods A 4-month-old child diagnosed with rhabdomyosarcoma of orbit was treated with multiagent chemotherapy (CTh) and brachytherapy. Pre-planning computed tomography (CT) images were obtained and clinical target volume (CTV) was defined using the pre-tr...

Oxidative stress has an important role in the degradation, oxidation, cross‑linking and aggregation of lens proteins, and can trigger lens epithelial cell apoptosis. To investigate the protective effect of chlorogenic acid (CGA) against hydrogen peroxide (H2O2)‑induced oxidative stress, human lens epithelial cells (hLECs) were exposed to various concentrations of H2O2 in the presence and absenc...

Lenses obtained from rats on a galactose diet for six days showed a marked reduction in their capacity to incorporate 35S-methionine into protein even though there was no reduction in the capacity of the lenses to incorporate 3H-thymidine and 3H-uridine into DNA and RNA, respectively. Therefore, lenses were incubated in media in which various putative cataractogenic factors were varied to deter...

Let us first recall our setting. In the toric case, there is a correspondence between n-dimensional nonsingular Fano varieties and ndimensional Fano polytopes, where the Fano varieties are biregular isomorphic if and only if the corresponding Fano polytopes are unimodularly equivalent. Here, given a lattice N of rank n, a Fano polytope Q ⊆ NR := N ⊗Z R is given as a lattice polytope containing ...

PURPOSE Posterior capsular opacification (PCO) is a common long-term complication of modern cataract surgery. We have shown that Zebularine, an inhibitor of DNA methylation, suppresses transforming growth factor-β (TGFβ)-induced lens epithelial cells (LECs)-myofibroblasts transdifferentiation. The purpose of this study is to evaluate the role that Zebularine plays in the inhibition of PCO patho...

Purpose To investigate the relationship between lens power and age as well as the relationship between lens power and axial length (AL) in Chinese children and adolescents. Methods The participants underwent a comprehensive ophthalmic examination that included AL, cycloplegic refraction, and Pentacam measurements. The crystalline lens power was calculated using Bennett's formula and then comp...

To assess more fully the risk to normal tissue exposed to accelerated heavy particles in the space program and during radiotherapy on earth, the cytopathological effects of a variety of doses of accelerated (570 MeV/amu) Argon ('"'Ar) ions on the rat lens were investigated. Time-course analyses of lenses exposed to a 1 Gy (100 rad)-dose revealed that the effects of the particles on mitotic inde...

The human arylamine N-acetyltransferases NAT1 and NAT2 are important xenobiotic-metabolizing enzymes involved in the detoxification and metabolic activation of numerous drugs and chemicals. NAT activity depends on genetic polymorphisms and on environmental factors. It has been shown that low NAT-acetylation activity could increase the risk of age-dependent cataract, suggesting that NAT detoxifi...