leptin, a circulating 16-kd polypeptide consisting of 167 amino acids, appears to be involved in the body weight homeostasis. moreover leptin plays an important role for the reproductive system, early embryogenesis, and fat metabolism during pregnancy and puberty. significant correlations have been found between leptin and sexual hormones, which is a cytokine and has hormonal properties. the ai...

introduction: ghrelin, increases food intake, decreases t3 and t4 concentrations and stimulates insulin release, while leptin reduces food intake and suppresses appetite. considering the importance of thyroid hormones, ghrelin and leptin in body metabolism, the purpose of this study was to investigate the effect of interactions between ghrelin and leptin (injected via icv route) and plasma t3 a...

introduction: leptin is an adipocyte-derived hormone. exogenous leptin allows the recovery of the reproductive function. in humans, leptin correlates positively with the body mass index (bmi). the aim of this study was to investigate the association of leptin with the toxic effects of iron overload. methods: 219 major beta thalassemic patients (119 men, 100 women) and 137 non thalassemic indivi...

background polypeptide hormone leptin suppresses inflammation in the heart muscle and protects heart from diseases. the purpose of this study is to evaluate the relationship between leptin and troponin serum levels with cardiac involvement in patients with major beta thalassemia. materials and methods in this cross-sectional study, 70 children with major thalassemia were selected. two ml blood ...

Abstract Introduction Individuals with obesity hypoventilation syndrome (OHS) are unable to increase ventilation match increased CO2 production (VCO2). Obstructive sleep apnea (OSA), defined by the closure of upper airway during sleep, is present in 90% OHS patients. Leptin, an adipocyte-produced hormone, acts leptin receptor (LEPRb) positive neurons and was implicated pathophysiology OSA OHS. ...

background: bladder cancer (bc) is the most commonly diagnosed genitourinary cancer in iran, presented in both men and women. bc is a multifactorial trait resulting from the complex interaction between several genes and environmental factors. long stress-induced non-coding transcript 5 (lsinct5), a member of the long non-coding rnas, is abundantly expressed in high proliferative cells, as well ...

Introduction: Leptin is a critical metabolic signal linking nutrition and reproductive functions. Leptin receptors are expressed in germ cells, Sertoli and Leydig cells. Oxidative stress increases sperm DNA damages. Nitric oxide is a free radical, produced by most cells via Nitric Oxide (NO) synthase and plays stimulatory and inhibitory roles on cells. Physiological concentrations of NO are ess...

The purpose of this study was to evaluate the probable effects of leptin addition in different levels to the semen extender on sperm quality (motility and motility parameters, viability, sperm membrane integrity, and DNA damage). Semen specimens were evaluated immediately after leptin addition, equilibration time and after thawing the frozen semen. Five healthy buffalo bulls (5 ejaculates from ...

Objective: There are a few studies related to nitric oxide (NO) and leptin interaction in the regulation of physiological events skeletal muscle. Therefore, aim present study is investigate NO response blood flow synthase (NOS) distribution on rat Materials Methods: Twenty-four adult-male Wistar albino rats were divided into 4 groups: control (C), Leptin (LP) (50 μg/kg), L-NG-nitroarginine meth...

Leptin-resistant rats have reduced leptin receptors and signaling and are refractory to exogenous leptin. However, it is unclear how leptin-mediated hypothalamic signal transducer and activator of transcription 3 (STAT3) signaling relates to the loss of physiological responsiveness. We hypothesized that if leptin resistance is associated with leptin receptors that are no longer functionally cou...