Case presentation: Patient RSP, female, born full-term and without complications during pregnancy or perinatally. She presented her first episode of tonic-clonic at 5 months age, evolving with recurrent seizures variable frequency intensity, neuropsychomotor development (NPMD), tremors in the upper limbs precocious puberty. Brain MRI diffuse leukoencephalopathy associated volumetric reduction. ...

BACKGROUND Unequivocal brain radiation-induced parkinsonism has so far been reported in only in two pediatric patients. However, with the rising incidence rates for brain tumors in industrialized countries and the consequential increased exposure to cranial radiotherapy, clinicians might become more exposed to this entity. CASE REPORT Three patients were treated for intraparenchymal brain tumor...

We report on a stem cell-transplanted patient with B cell chronic lymphatic leukemia who presented with a subacute onset of focal neurological deficits, gait abnormalities, emotional lability and dementia. Progressive multifocal leukoencephalopathy was diagnosed by magnetic resonance imaging (MRI) of the brain and detection of JC virus genome in the cerebrospinal fluid. Cidofovir and the 5HT2A ...

Progressive multifocal leukoencephalopathy (PML) is a demyelinating brain disease caused by Jamestown Canyon virus (JCV). This disease is an important cause of morbidity and mortality in acquired immunodeficiency syndrome (AIDS) patients. We report a 34-year-old man infected with HIV-1 who presented with frequent general tonic clonic seizure and left side weakness for 2 months. Clinical feature...

1. Lopes da Silva R. Polyoma BK virus: an emerging opportunistic infectious agent of the human central nervous system. Braz J Infect Dis. 2011; 15: 276-84. 2. Reploeg MD, Storch GA, Clifford DB. BK virus: a clinical review. Clin Infect Dis. 2001; 33:191-202. 3. Hix JK, Braun WE, Isada CM. Delirium in a renal transplant recipient associated with BK virus in the cerebrospinal fluid. Transplantati...

In June 1996, NINDS and Johns Hopkins University Department of Neurology organized a 1‰ day workshop, `HIV Neurologic Therapies Workshop'. The principal objective of the Workshop was to facilitate the development of innovative therapeutic strategies for dementia, neuropathy, neurologic CMV disease, and progressive multifocal leukoencephalopathy (PML). Separate groups focused on different neurol...