background and aims. oral lichen planus (olp) is a common chronic mucocutaneous disease. patients with atrophic and erosive lichen planus often have symptoms of soreness and need proper treatment. the main therapy of olp has been the administration of topical or systemic corticosteroids. potent topical corticosteroids have been increasingly prescribed in the treatment of erosive lichen planus. ...

Multiple sclerosis and lichen ruber planus are clinically and histologically distinct complex disorders of putative autoimmune aetiology that are fairly commonly observed in isolation but rarely found in combination. Only two previous reports have described lichen skin disorders in association with multiple sclerosis. The present report describes the case of a 51-year-old Caucasian woman exhibi...

background and aims. oral lichen planus (olp) is an immunologic disorder. a large number of studies have reported that lipid rafts have a key role in receptor signaling of lymphocytes. here, we explore the potential of lipid rafts as targets for the development of a new class of agents to down-modulate immune responses and treat autoimmune diseases. materials and methods. the present cross-sect...

Introduction: Lichen planus is a human exclusive, chronic inflammatory disease affecting skin and mucosa, particularly oral mucosa affecting the stratified squamous epithelia. Epithelial alterations in oral lichen planus (OLP) may lead to superimposed Candida infection, especially the normal flora Candida albicans. Therefore, this study was designed to assess the prevalence of Candida infection...

The close chromosomal proximity of major histocompatibility complex and tumour necrosis factor genes may suggest the involvement of the latter in the pathogenesis of immunological diseases associated with HLA antigenes. The major histocompatibility complex antigens may play a certain role in the pathogenesis of lichen planus. Therefore we examined the -308 promoter polymorphism of tumour necros...

Sir, Chronic graft-versus-host disease (GVHD) occurs in approximately 60 – 80% of patients who survive for 100 days after allogeneic bone marrow transplantation (BMT) (1). The skin is affected in almost all cases of chronic GVHD, with two distinct phases: the early chronic phase, characterized by lichenoid lesions similar to lichen planus, and the late chronic phase, with sclerodermatous lesion...

Lichen planus Drug Metformin Dr. Reuven Bergman, Department of Dermatology, Rambam Medical Center, POB 9602, 31096 Haifa (Israel) Lichen planus is a relatively common skin disorder of unknown etiology. A wide variety of drugs have been implicated in its cause, although in many cases there is insufficient evidence to differentiate them from the idiopathic disorder [1]. Among the oral hypoglycemi...