First, Schiff base iminopyridine ligand has been prepared by the condensation between primary amine, dimethylaniline and active carbonyl group of pyridine carboxaldehyde, then related complexes were synthesized in methanol solution. The ligand and metal complexes have been characterized by elemental analysis, UV, IR, 1 H NMR and 13CNMR spectroscopy. The spectroscopic data of metal complexes ind...

hirchsprung’s disease is a developmental disorder of the enteric nervous system, characterized by abdsence of ganglion cell in the myenterric and submucosal plexuese along a variable portion of the distal intestine.the purpose of this study is the presentation of a new procedure for reduction of the postoperative complications of hirschsprung’s disease (hd) by offering a modified swenson’s tech...

background: visceral leishmaniasis is systematic serous parasitic disease with pub­lic health importance. zoonotic form of visceral leishmaniasis is wide spread in mediterranean basin and south america regions. direct agglutination test (dat) is an accurate, reliable and non-expensive serological test for the diagnosis of visceral leishmaniasis in human and canines but the antigen preparation i...

chromium (vi) adsorption behavior and capacity by surface modified nanozeolite a has been investigated. surface modification was performed and the morphology of modified and unmodified nanozeolite was studied using scanning electron microscope (sem) and transmission electron microscope (tem). adsorption isotherms were studied under different conditions (ph, adsorbent dose, adsorbate concentrati...

this paper provides an overview of how the surface properties of ferromagnetic nanoparticles dispersed in fluids is modified by natural and biocompatible polymers. among common magnetic nanoparticles, magnetite (fe3o4) and maghemite (g-fe203) are popular candidates because of their biocompatibility. natural polymeric coating materials are the most commonly used biocompatible magnetic nanopartic...

this study aims to design some dual-target anticancer candidates, capable to act as an alkylating agent as well as a thymidylate synthase (ts) inhibitor. the designed scaffold is a combination of nucleobase, amino acid and aziridine structures. the candidates are docked into ts and three dna double strand structures and evaluated based on their binding interaction energies and ligand efficienci...

In recent years, radiometals have been successfully applied to medicine because of their breadth decay properties and increased production availability. Bifunctional chelators play a key role in radiometal-based radiopharmaceuticals, affecting the labeling, targeting, pharmacokinetics bioconjugations ensuring stable complexation metal vivo. The capacity macrocycles form complexes with extremely...

Hemin/G-quadruplex (hGQ) DNAzymes are horseradish peroxidase-mimicking catalysts capable of the oxidation a variety substrates. We now implement aptamer-functionalized hGQ DNAzymes, also known as nucleoapzymes, to achieve increased bioconjugation N-methyl luminol tyrosine-containing residues and peptides. found that presence tyrosinamide-binding aptamer leads 12-fold increase in catalytic rate ...