نتایج جستجو برای: like receptor 3

تعداد نتایج: 2770821  

2012
Piyali Chatterjee Laura E. Weaver Karen M. Doersch Shelley E. Kopriva Valorie L. Chiasson Samantha J. Allen Ajay M. Narayanan Kristina J. Young Kathleen A. Jones Thomas J. Kuehl Brett M. Mitchell

Preeclampsia (PE) is a pregnancy-specific hypertensive syndrome characterized by excessive maternal immune system activation, inflammation, and endothelial dysfunction. Toll-like receptor (TLR) 3 activation by double-stranded RNA (dsRNA) and TLR7/8 activation by single-stranded RNA (ssRNA) expressed by viruses and/or released from necrotic cells initiates a pro-inflammatory immune response; how...

2011
Piyali Chatterjee Valorie L. Chiasson Shelley E. Kopriva Kristina J. Young Victor Chatterjee Kathleen A. Jones Brett M. Mitchell

Preeclampsia may result from overactivation of the maternal immune system and is characterized by endothelial dysfunction and excessive inflammation. Given the importance of maternal immune system regulation and antiinflammatory cytokines in normotensive pregnancies, we hypothesized that maternal immune system activation via Toll-like receptor 3 during pregnancy would cause preeclampsia-like sy...

Journal: :Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2014

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